RISK FACTORS FOR AGE-RELATED EYE DISEASES

描述：(候选人摘要)这是一份修改后的申请表 K08(前身为K11)奖，以培训Debra Schaumberg博士 流行病学。该项目包括流行病学的研究生课程。 哈佛公共卫生学院(HSPH)的生物统计学， 预防医学部的研讨会和研究会议 在布里格姆妇女医院和HSPH，以及在 继续指导哈佛大学教授查尔斯·亨内肯斯博士 医学和流行病学。职业发展的总体目标 计划是：1)在流行病学方面奠定坚实的学术基础， 包括完成哈佛大学理学博士学位，以及2)整合 以实践研究经验指导学习，以求进步 成为一名独立的研究人员。以前的研究已经提出了 白内障、老年性黄斑变性(AMD)和 心血管疾病(CVD)可能具有共同的危险因素。建议数 研究将调查心血管疾病危险因素与 白内障和黄斑变性。该项目与健康相关的地方在于 白内障和老年性黄斑变性是导致失明和视力障碍的主要原因 全世界。研究计划的具体目标是：1)确定 白内障的潜在独立预测因素包括高血压， 抗高血压药物和体重变异性；以及2) 调查AMD是否与CVD有共同的风险因素 特别是高血压，降压药，体重指数， 体力活动和饮食因素，包括饱和脂肪、omega-3 脂肪酸和类胡萝卜素。研究方法：本研究将从 作为国家眼科研究所资助的一部分收集的数据 维生素补充剂的随机试验与眼病的亚研究 正在进行的医生健康研究。这将提供一个独特的 熊伯格博士有机会进行前瞻性观察 使用基线和更新的风险因素信息进行的研究，并确认 记录了更多白内障和老年性黄斑变性事件的自我报告 对22,071名男性进行了长达12年的随访。的长期目标是 这项研究将有助于更好地理解病因学。 以及这些常见致盲疾病的风险因素，以便取得进展 对他们的预防作出努力。

DESCRIPTION: (Candidate's Abstract) This is a revised application for a K08 (formerly K11) Award to train Dr. Debra Schaumberg in epidemiology. The program consists of graduate courses in epidemiology and biostatistics at the Harvard School of Public Health (HSPH), seminars and research meetings at the Division of Preventive Medicine at the Brigham and Women's Hospital and HSPH, and research under the continued mentorship of Dr. Charles Hennekens, Harvard Professor of Medicine and Epidemiology. The overall goals of the career development plan are: 1) to develop a strong academic foundation in epidemiology, including completion of the Harvard Sc.D. degree, and 2) to integrate didactic learning with hands-on research experience in order to progress into an independent researcher. Previous studies have raised the possibility that cataract, age-related macular degeneration (AMD), and cardiovascular disease (CVD) may share common risk factors. The proposed studies will investigate the commonality of CVD risk factors with cataract and AMD. The health-relatedness of the project is that cataract and AMD are leading causes of blindness and visual impairment worldwide. The specific aims of the research plan are: 1) to identify potential independent predictors of cataract including hypertension, antihypertensive medications, and body weight variability; and 2) to investigate whether AMD shares common risk factors with CVD, in particular hypertension, antihypertensive medications, body mass index, physical activity, and dietary factors including saturated fats, omega-3 fatty acids, and carotenoids. Methods: The research will emanate from data being collected as part of the National Eye Institute-funded Randomized Trials of Vitamin Supplements and Eye Disease substudy of the ongoing Physicians' Health Study. This will provide a unique opportunity for Dr. Schaumberg to perform prospective observational studies using baseline and updated risk factor information and confirmed self-reports of incident cases of cataract and AMD documented over more than 12 years of follow-up of 22,071 men. The long-term objective of this research is to contribute to a better understanding of the etiology and risk factors for these common blinding diseases so that progress can be made toward their prevention.