CORE--CLINICAL

阿尔茨海默病（AD）仍然是一种排除性诊断。 然而，在这方面， 研究标准已经发展到允许死前诊断 具有较高的效度、信度和敏感度。 临床 核心负责招聘、评估和维护 AD受试者和年龄匹配的健康对照人群， 可供调查，并促进分析数据， 这些活动。 临床核心有4个组成部分：1。患者登记系统 组件; 2.神经心理学组件; 3.精神病理学部分; 4. 数据管理和分析组件（DMAC）。 的职能 患者登记组件负责招募、表征和重新评价 病例和对照;并协调受试者的研究活动， 护理人员，包括CERAD活动和尸检。 神经心理学 成分测试受试者提供疾病的定量测量 使用标准化评估。 精神病理学部分 提供当前精神病理学的评估，以及个人和 精神病家族史 DMAC的功能是 促进数据的收集和计算机化，维护 数据库，以协助研究者设计和执行数据 分析计划，并支持核心的信息管理需求 和项目

Alzheimer's disease (AD) remains a diagnosis of exclusion. However, research criteria have been developed to allow for pre-mortem diagnosis with relatively high validity, reliability and sensitivity. The Clinical Core is responsible for recruiting, evaluating and maintaining a population of subjects with AD and healthy age-matched controls who are available for investigation, and for facilitating analyses of data from these activities. There are 4 components to the Clinical Core: 1. Patient Registry Component; 2. Neuropsychology Component; 3. Psychopathology Component; 4. Data Management and Analysis Component (DMAC). The functions of the Patient Registry Component are to recruit, characterize, and re-evaluate cases and controls; and to coordinate research activities of subjects and caregivers, including CERAD activities and autopsy. The Neuropsychology Component tests subjects to provide quantitative measures of disease effects, using a standardized evaluation. The Psychopathology Component provides assessments of current psychopathology, as well as personal and family history of psychopathology. The functions of DMAC are to facilitate the collection and computerization of data, maintain the database, to assist investigators in the design and execution of data analysis plans, and to support the information management needs of cores and projects.