BIOLOGICAL AND PHARMACOLOGICAL ASSESSMENT OF GPIIB/IIIA RECEPTOR

糖蛋白（GP）IIb/IIIa是整合素超家族的成员 膜结合粘附分子。 血小板膜糖蛋白 是高度多态性的，并且可以被识别为同种或自身抗原。 不同血小板表面表位的不相容性 糖蛋白是同种免疫性血小板减少症的原因。 的 同种抗原最常涉及免疫介导的 血小板破坏是PLA（或Zw）。 一项病例对照研究显示， PlA 2等位基因与不稳定冠状动脉粥样硬化之间存在强相关性， 综合征，特别是在小于60岁的个体中。 然而，随后的研究并没有证实这一观察结果。 本研究旨在描述Gp IIb/IIa基因型及其与临床的关系。 与北美健康受试者的纤维蛋白原结合相关。 将对糖蛋白（Gp）IIb/IIa进行基因型分析 对100名健康志愿者的GP IIb/IIIa之间的相关性 基因型和纤维蛋白原结合的程度将在 30个个体的亚组（15个平衡对）。

The glycoprotein (Gp) IIb/IIIa is a member of the integrin superfamily of membrane-bound adhesion molecules. Platelet membrane glycoproteins are highly polymorphic and can be recognized as allo-or self-antigens. Incompatibility of epitopes on the various pletelet surface glycoproteins is responsible for the alloimmune thrombocytopenias. The alloantigen most frequently implicated in syndromes of immune mediated platelet destruction is PLA (or Zw). A case-control study has shown a strong association between the PlA2 allele and unstable coronary syndromes, especially in individuals less than 60 years of age. However, subsequent studies did not confirm this observation. The present study wants to characterize the Gp IIb/IIa genotype and its correlation with fibrinogen binding in healthy North-American subjects. Genotypic analyses of the glycoprotein (Gp) IIb/IIa will be performed on 100 healthy volunteers and the correlation between the GP IIb/IIIa genotype and the extent of fibrinogen binding will be assessed in a subgroup of 30 individuals (15 balanced pairs).