EFFECTS OF LIPID LOWERING ON CORONARY INTIMAL STRUCTURE AND ENDOTHELIAL FUNCTION

许多研究已经表明，治疗患有 高血压和确诊的冠状动脉疾病（CAD导致 显著减少后续临床事件，如心肌梗死 心肌梗死（MI）和死亡，尽管有少量改善， 血管造影狭窄程度。 不仅是机械装置造成的 差异不清楚，缺乏临床事件的替代品， 研究降脂治疗的益处是困难的。 我们将 检查血管内超声对心外膜血管的影响， 冠状动脉内皮功能和阻力血管功能 通过对乙酰胆碱和腺苷的反应评估循环， 受试者将是已知和记录的冠状动脉 疾病，和中度升高的LDL胆固醇水平。

A number of studies ahve shown that treatment of patients with hyprlipidemia and established coronary artery disease (CAD results in marked reduction of subsequent clinical events such as myocardial infarction (MI) and death, in spite of small amounts of improvement in angiographic degree of stenosis. Not only is the mechanism causing this discrepancy unclear, the lack of a surrogate for clinical events makes studies of the benefits of lipid lowering therapy difficult. We will examine the effect of intravascular ultrasound, and on epicardial vessel endothelial function and resistance vessel function in the coronary circulation assessed by the response to acetylcholine and adenosine, in subjects will be patients with known and documented coronary artery disease, and a moderately elevated LDL cholesterol level.