ANTIOXIDANT RESPONSE TO VITAMIN E ADMINISTRATION

本研究的主要目的是表征抗氧化剂 补充维生素E的效果。 为此两部小说在体内 将测量氧化应激的标志物：8-epi-PGF（2 α）和8-epi-PGF（2 α）。 oxodG。 研究的具体目标是：i）确定 最佳剂量的维生素E需要达到最大的抗氧化效果。 ii）确定达到最大抗氧化效果的时间过程 以确定抗氧化作用的持续时间， 维生素E iv）停药，以比较两种新的 氧化应激的标志物。

The primary objective of this study is to characterize the antioxidant effect of Vitamin E supplementation. To this end two novel in vivo markers of oxidative stress will be measured: 8-epi-PGF (2 alpha) and 8- oxodG. The specific objectives of the study are: i) to determine the optimum dose of vitamin E required to reach maximum antioxidant effect. ii) to establish the time course to reach maximal antioxidant effect iii) to establish the duration of the antioxidant effect following discontinuation of vitamin E iv) to compare the efficacy of two novel markers of oxidative stress.