CORE--NEUROIMAGING

神经影像学在诊断和鉴别诊断中的重要性日益增加 痴呆症的诊断 需要成像以满足研究诊断 可能是阿尔茨海默病，血管性痴呆， 额颞叶痴呆症和其他痴呆症 的活动 的成像核心与美国国立卫生研究院资助的人脑成像 项目 加州大学洛杉矶分校有一个发达的成像程序和神经成像是 加州大学洛杉矶分校阿尔茨海默病中心（ADC）的核心优势之一。 到目前为止，已经获得了634张结构和功能图像， 分析了 为理解这种关系做出了贡献 AD的遗传状态与成像以及 额颞叶痴呆和血管性痴呆。 在更新期间，我们 将通过进一步的 在ADC网络上开发连接UCLA ADC站点的成像节点; 提高不同ADC部位图像的标准化; ADC中研究患者的影像学、临床和病理改变; 开发痴呆症患者脑成像的新技术;以及 继续发展一个有利于成像研究的环境， 训练 Imaging Core将与 教育/信息传递核心，以培训ADC人员， 解释结构和功能图像的变化。 UCLA ADC研究中心 可以获得前所未有的神经成像资源。 计算机断层扫描（CT）和磁共振成像（MRI）是 可在所有站点;磁共振波谱（MRS）是 在Harbor-UCLA和UCLA医学中心运行;正电子发射 断层扫描（PET）可在加州大学洛杉矶分校医学中心和西洛杉矶退伍军人 事务医学中心;单光子发射计算机断层扫描 （SPECT）可从所有研究中心获得; QEEG可在所有研究中心获得 除了Drew/King;功能性MRI在加州大学洛杉矶分校医学中心运行 正在加州大学洛杉矶分校的哈博研发。 加州大学洛杉矶分校的低温大切片机 人类头部的切片，每个切片的数字化，以及随后的 图像的计算机化重建。 这些图像可以被研究， 解决有关成像与病理学关系的问题。 成像核心已经做出了重要贡献，并准备做出 续延期内的额外预付款。

Neuroimaging has increasing importance in the diagnosis and differential diagnosis of dementia. Imaging is required to meet research diagnostic criteria for probable Alzheimer's disease, vascular dementia, frontotemporal dementias, and other dementing disorders. The activities of the Imaging Core are integrated with the NIH-funded Human Brain Imaging Project. UCLA has a well developed imaging program and neuroimaging is one of the central strengths of the UCLA Alzheimer's Disease Center (ADC). Thus far, 634 structural and functional images have been obtained and analyzed. Contributions have been made to understanding the relationship of genetic status to imaging in AD as well as to imaging alterations in frontotemporal dementias and vascular dementia. In the renewal period we will enhance the availability of imaging results through further development of the imaging node on the ADC net linking UCLA ADC sites; increase standardization of images across different ADC sites; correlate imaging, clinical and pathological changes of patients studied in the ADC; develop new techniques for brain imaging of dementia patients; and continue to develop an environment that facilities imaging research and training. The Imaging Core will collaborate with the Education/Information Transfer Core to train ADC personnel to reliably interpret changes in structural and functional images. UCLA ADC sites have access to an unprecedented breadth of neuroimaging resources. Computerized tomography (CT) and magnetic resonance imaging (MRI) are available at all sites; magnetic resonance spectroscopy (MRS) is operational at Harbor-UCLA and UCLA Medical Center; positron emission tomography (PET) is available at UCLA Medical Center and West LA Veterans Affairs Medical Center (VAMC); single photon emission computed tomography (SPECT) can be procured from all sites; QEEG can be obtained at all sites except Drew/King; and functional MRI is operational at UCLA Medical Center and is being developed at Harbor-UCLA. A cryomacrotome at UCLA allows slicing of human heads, digitization of each slice, and subsequent computerized reconstruction of the images. These images can be studied to address questions relevant to the relationship of imaging to pathology. The Imaging Core has made an important contributions and is poised to make additional advances in the renewal period.