PLASTICITY OF GABA RECEPTORS

在这个项目申请中，一个由三名独立教员组成的小组 在同一家机构加州大学洛杉矶分校，他们在 电生理学、神经解剖学、生物化学和分子生物学 探讨基础神经生物学中的重要问题 对任何一个人来说都很难。选择用于协作的主题 研究内容是“GABA受体的可塑性”。项目总监理查德·奥尔森 就像GABA/A受体本身的结构一样，组装了一个 科学家的“杂寡体”。奥尔森的组件项目是 “苯并二氮类药物诱导GABA/A受体可塑性”。卡罗琳·豪泽的 项目名为“GABA/A受体亚基定位的可塑性”，以及 涉及慢性癫痫大鼠点燃模型的建立。所有项目 重点关注GABA/A受体，主要的突触后受体参与 快速抑制神经传递。这些受体和“塑料” 它们发生的变化是对各种非同寻常的 经历，牵涉到许多神经学和精神病学 精神错乱。所采用的各种技术保证了一定程度的 调查旨在了解装配、功能和 哺乳动物神经系统中GABA/A受体的可塑性。两者都是 希望并期望拟议的研究将成为 探索性协作揭开了对 哺乳动物大脑中的抑制作用。建议的研究涉及 分子结构和功能变化的性质 GABA/A受体参与慢性兴奋性改变 神经元耐受和慢性药物戒断的机制 曝光。最终，治疗策略可以基于我们的 理性地研究，旨在防止不受欢迎的或病态的 几种神经性疾病患者GABA/A受体的改变 精神障碍。

In this program project application, a group of three independent faculty at the same institution, UCLA, have combined expertise in electrophysiology, neuroanatomy, biochemistry, and molecular biology to approach important questions in basic neurobiology which would be difficult for any one individual. The them chosen for collaborative research is "Plasticity of GABA Receptors". Program Director Richard Olsen has assembled, like the structure of GABA/A receptors themselves, a "heterooligomer" of scientists. Olsen's component project is 'Benzodiazepine-induced GABA/A receptor plasticity'. Carolyn Houser's project is 'Plasticity of GABA/A receptor subunit localization', and involves the kindling model of chronic epilepsy in rats. All projects focus on GABA/A receptors, the major postsynaptic receptors involved in rapid inhibitory neurotransmission. These receptors, and 'plastic' alterations in them that occur in response to a variety of extraordinary experiences, are implicated in many neurological and psychiatric disorders. The wide variety of employed techniques promises a level of investigation aimed at understanding the assembly, functioning, and plasticity of GABA/A receptors in the mammalian nervous system. It is both hoped and expected that the proposed studies will serve as a leading inquisitive collaboration to unveil the short and long-term control of inhibition in the mammalian brain. The proposed studies deal with the nature of the alterations in the molecular structure and function of GABA/A receptors that contribute to chronic changes in excitability of neurons or to the mechanism of tolerance and withdrawal from chronic drug exposure. Ultimately, therapeutic strategies could be based on our studied, aimed rationally at preventing the unwanted or pathological alterations in GABA/A receptors characteristic of several neurological and psychiatric disorders.