CORE--NEUROIMAGING

神经影像在诊断和鉴别诊断中的重要性日益增加。 痴呆症的诊断。成像是满足研究诊断所必需的 可能患有阿尔茨海默病、血管性痴呆、 额颞部痴呆和其他痴呆症。活动 的成像核心与NIH资助的人脑成像相结合 项目。加州大学洛杉矶分校有一个完善的成像程序，而神经成像是 加州大学洛杉矶分校阿尔茨海默氏症中心(ADC)的核心优势之一。 到目前为止，已获得634幅结构和功能图像，并 分析过了。已经为理解这种关系做出了贡献 遗传状态对AD的成像以及对AD的成像改变 额颞痴呆和血管性痴呆。在续约期内，我们 将通过进一步提高成像结果的可用性 开发连接加州大学洛杉矶分校ADC站点的ADC网络上的成像节点； 提高跨不同ADC站点的图像标准化；关联 ADC研究患者的影像、临床和病理变化； 开发痴呆症患者脑成像的新技术；以及 继续发展一个有利于成像研究和 训练。成像核心将与 教育/信息传输核心，用于培训ADC人员以可靠地 解读结构和功能图像中的变化。加州大学洛杉矶分校ADC网站 可以获得前所未有的广泛的神经成像资源。 计算机断层扫描(CT)和磁共振成像(MRI)是 在所有站点都可用；磁共振波谱(MRS)是 在港湾-加州大学洛杉矶分校和加州大学洛杉矶分校医疗中心工作；正电子发射 加州大学洛杉矶分校医学中心和西洛杉矶退伍军人中心提供断层扫描(PET) 事务医学中心(VAMC)；单光子发射计算机断层扫描 (SPECT)可从所有站点获得；qEEG可在所有站点获得 除了德鲁/金；加州大学洛杉矶分校医疗中心有功能核磁共振 目前正在由加州大学洛杉矶分校的港湾分校开发。加州大学洛杉矶分校的冷冻巨噬细胞允许 对人的头部进行切片，对每一张切片进行数字化，然后 图像的计算机重建。这些图像可以用来研究 解决与影像与病理学的关系相关的问题。 成像核心已经做出了重要贡献，并准备做出 续订期间的额外预付款。

Neuroimaging has increasing importance in the diagnosis and differential diagnosis of dementia. Imaging is required to meet research diagnostic criteria for probable Alzheimer's disease, vascular dementia, frontotemporal dementias, and other dementing disorders. The activities of the Imaging Core are integrated with the NIH-funded Human Brain Imaging Project. UCLA has a well developed imaging program and neuroimaging is one of the central strengths of the UCLA Alzheimer's Disease Center (ADC). Thus far, 634 structural and functional images have been obtained and analyzed. Contributions have been made to understanding the relationship of genetic status to imaging in AD as well as to imaging alterations in frontotemporal dementias and vascular dementia. In the renewal period we will enhance the availability of imaging results through further development of the imaging node on the ADC net linking UCLA ADC sites; increase standardization of images across different ADC sites; correlate imaging, clinical and pathological changes of patients studied in the ADC; develop new techniques for brain imaging of dementia patients; and continue to develop an environment that facilities imaging research and training. The Imaging Core will collaborate with the Education/Information Transfer Core to train ADC personnel to reliably interpret changes in structural and functional images. UCLA ADC sites have access to an unprecedented breadth of neuroimaging resources. Computerized tomography (CT) and magnetic resonance imaging (MRI) are available at all sites; magnetic resonance spectroscopy (MRS) is operational at Harbor-UCLA and UCLA Medical Center; positron emission tomography (PET) is available at UCLA Medical Center and West LA Veterans Affairs Medical Center (VAMC); single photon emission computed tomography (SPECT) can be procured from all sites; QEEG can be obtained at all sites except Drew/King; and functional MRI is operational at UCLA Medical Center and is being developed at Harbor-UCLA. A cryomacrotome at UCLA allows slicing of human heads, digitization of each slice, and subsequent computerized reconstruction of the images. These images can be studied to address questions relevant to the relationship of imaging to pathology. The Imaging Core has made an important contributions and is poised to make additional advances in the renewal period.