VIRAL GENES AS TARGETS FOR ANTIVIRAL DRUGS

我们研究的总体目标是确定新的化合物， 有可能成为有用的抗病毒药物， 有前途的化合物如何在细胞、分子和生物化学方面发挥作用 水平 为此，我们通过体外选择方法 人类巨细胞病毒（HCMV）和人类免疫缺陷病毒（HIV） 对活性化合物具有抗性的菌株。 利用抗药性 作为一个标记，我们正在确定哪些HCMV和HIV 基因突变产生抗药性病毒株。 这些基因的鉴定提供了对 抗病毒药物作用。 此外，由基因指定的蛋白质 可能是抗病毒药物的新靶点。 具体目标 需要使用GCG分析软件的方法是比较 病毒基因与相关的病毒、哺乳动物和原核生物基因 为了更好地了解病毒基因的功能和 新的抑制剂

The overall objective of our research is to identify new compounds which have the potential to become useful antiviral drugs and to investigate how promising compounds act at the cellular, molecular and biochemical level. Toward this end, we have derived by in vitro selection methods human cytomegalovirus (HCMV) and human immunodeficiency virus (HIV) strains which are resistant to active compounds. Using drug resistance as a marker, we are in the process of identifying which HCMV and HIV genes have mutated to produce drug resistant virus strains. Identification of such genes is providing detailed understanding of antiviral drug action. Furthermore, the proteins specified by the genes may be new targets for antiviral drugs. The specific objective requiring the use of GCG analysis software is to compare the sequence of the viral genes to related viral, mammalian, and prokaryotic genes to better understand the function of the viral gene and the action of new inhibitors.