INVESTIGATION OF A POSSIBLE ASSOCIATION BETWEEN MYCOPLASMA SPECIES AND ASTHMA

哮喘是一种以气道可逆为特征的临床综合征 阻塞、气道炎症和对多种 的刺激。然而，发病机制仍然不明确。 某些微生物与哮喘的恶化有关， 特别是病毒、衣原体和肺炎支原体。 几 研究表明，感染M.肺炎导致增加 非哮喘患者气道高反应性和气流阻塞 感染后可持续数年的患者。 此外， 可以产生类似于哮喘的气道疾病的动物模型， 肺支原体 我们假设慢性稳定型 哮喘会表现出支原体的证据， 航空公司. 此外，使用克拉霉素（一种大环内酯类， 已知的抗支原体的活性，将导致 他们的哮喘

Asthma is a clinical syndrome characterized by reversible airway obstruction, airway inflammation and hyperresponsiveness to a wide variety of stimuli. However, the pathogenesis has remained poorly defined. Certain microorganisms have been implicated in the exacerbation of asthma, particularly viruses, chlamydia and Mycoplasma pneumoniae. Several studies have shown that infection with M. pneumoniae results in increased bronchial hyperresponsiveness and airflow obstruction in non-asthmatic patients that can last several years after infection. In addition, an animal model of airway disease similar to asthma can be produced with Mycoplasma pulmonis. We hypothesized that patients with chronic, stable asthma would exhibit evidence of mycoplasma in the upper and lower airways. Furthermore, treatment with clarithromycin, a macrolide with known activity against mycoplasma species, would result in improvement in their asthma.