COCAINE EXPOSED INFANTS--CARDIAC PROBLEMS AND OUTCOME

怀孕期间使用可卡因的母亲所生的婴儿有更大的 发病率和较高的猝死率。突发事件的病因学 死亡原因尚不清楚。初步观察表明， 多发性心血管异常，如左心室大 大量人群、持续性高血压、ST段抬高 高度和更高的迷走神经张力。研究其对心血管的影响 关于宫内可卡因暴露，这项研究的目的如下： 检测新生儿期心血管异常； 脐血胆碱酯酶活性与脐带血胆碱酯酶活性的关系 以及上述异常；并研究这些异常的自然历史 在生命的头两个月中出现异常。

Infants born to mother who use cocaine during pregnancy have greater morbidity and a higher rate of sudden death. The etiology of sudden death is unclear. Preliminary observations suggest the presence of multiple cardiovascular abnormalities such as greater left ventricular mass, persistent hypertension, greater prevalence of ST segment elevations and higher vagal tone. To study the cardiovascular effects on in-utero cocaine exposure the study has the following aims: to detect the cardiovascular abnormalities in the newborn period; to evaluate the relationship of cord blood plasma cholinesterase activity and the above abnormalities; and to study the natural history of these abnormalities during the first 2 months of life.