HUMAN CEREBRAL GABA METABOLISM STUDIES IN VIVO WITH MR SPECTROSCOPY

我们建议研究脑谷氨酸和GABA周转住院患者 癫痫的1H和13 C核磁共振波谱分析。对两部小说的回应 抗癫痫药物将作为探针，以澄清代谢 对GABA水平升高的反应。 我们继续研究GABA在体内速率与 合成、谷氨酸和脱羧酶（GAD）活性以及GABA 浓度. 评估人脑GABA增加对 作为GABA-A受体标记物的苯二氮卓受体的表达 使用连续单光子发射计算机断层扫描（SPECT）和1H 磁共振波谱（1H NMRS）。 探索机制 与加巴喷丁后人脑GABA增加相关 使用连续测量的脑细胞死亡率来给药 谷氨酸，GABA和谷氨酰胺周转前后， 给药加巴喷丁。

We propose to study brain glutamate and GABA turnover inpatients with epilepsy using combined lH and 13C NMRS. The responses to two novel anti-epileptic drugs will serve as probes to clarify the metabolic response to increased levels of GABA. We continue to investigate the relationship between in vivo rate of GABA synthesis, glutamic acid and decarboxylase (GAD) activity , and GABA concentration. Assess the effects of increased Human Brain GABA on the expression of Benzodiazepine receptors as a marker for GABA-A receptors using serial single photon emission computer tomography (SPECT) and 1H Magnetic Resonance Spectroscopy (1H NMRS). Explore the mechanisms associated with the increase in human brain GABA following Gabapentin administration using serial measurements of the rate of cerebral glutamate, GABA, and glutamine turnover before and after the administration of Gabapentin.