MODEL OF HANTA PULMONARY SYNDROME USING HANTA SIN NOMBRE VIRUS

1993年夏天，在四个人中发现了一种新的综合征。 美国的角落地区，由一个以前未知的 本扬病毒（Hanta sin nombre）。 虽然病毒是全身发现， 死于感染的患者，肺部发病机制 仍有待阐明。 在这种程度上，6只恒河猴被 鼻内或iv. 所有动物均显示无 临床症状和病毒负荷仍然很低甚至检测不到。 的 然而，动物的抗体滴度、低水平的IFNK和 病毒特异性细胞介导的应答。 的性质和规模 目前正在对这些反应进行评估， 与在人类患者上获得的值进行比较。

During summer of 1993, a novel syndrome was identified in the Four Corners area of the United States, caused by a previously unknown bunyavirus (Hanta sin nombre). While virus is found systemically in patients that died from the infection, the pulmonary pathogenesis remains to be elucidated. To that extent, 6 rhesus macaques were infected with HSNV either intranasally or iv. All animals showed no clinical symptoms and viral burdens remained low to undetectable. The animals responded however with antibody titers, low levels of IFNK and virus specific cell mediated responses. The nature and magnitude of these responses are currently being evaluated and will be compared with values obtained on human patients.