PHARMACOLOGIC EVALUATION OF 3 DOSES OF TESTOSTERONE IN MEN WITH HYPOGONADISM

这项研究是一项单中心、开放标记的研究，旨在评估 含睾酮的凝胶剂的药效学和药代动力学研究 渗透促进剂SEPA(MC-T Gel)递增给药 (0.25克到1.0克)给性腺功能减退的男性。我们的目标是确定 这种新的睾酮制剂对循环睾酮的影响 级别。此外，血清睾酮水平将达到 在对安德鲁姆(Smith-Kline Beecham)的反应中看到的，一种透皮剂 商业上可以买到的睾丸素制剂。有耐心的 由于较大的表面积，仙女座的接受度并不高。 贴片和明显的皮肤刺激性。希望MC-T 凝胶将被证明是一种新的、更灵活的治疗方法，可用于 性腺功能低下的男人。

This study is a single-center, open labeled study to evaluate the effects and pharmacokinetics of a gel containing testosterone and the penetration enhancer, SEPA (MC-T Gel), when adminsitered in rising doses (0.25gm to 1.0gm) to men with hypogonadism. The goal is to identify the effects of this new testosterone prepartion on circulating testosterone levels. In addition, serum testerone levels will be comared to those seen in response to Androderm (Smith-Kline Beecham), a transdermal testosterone preparation that is commerically available. Patient acceptance of Androderm has not been high, due to the large surface area of the patches and significant skin irritation. It is hoped that MC-T gel will turn out to be new, more flexible treatment, option for hypogonadal men.