课题基金 / 基金详情

SEARCH FOR THE IDDM GENES WITHIN THE HLA REGION IN AFRICAN AMERICANS

SEARCH FOR THE IDDM GENES WITHIN THE HLA REGION IN AFRICAN AMERICANS
在非裔美国人的 HLA 区域寻找 IDDM 基因
批准号:
6280835
负责人:
HENRY A ERLICH
金额:
$2.39万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 1998-11-30

项目摘要

项目成果

HENRY A ERLICH的其他基金

相关文献

中文摘要
翻译
很少有研究对患有糖尿病的非裔美国人进行人类白细胞抗原分型,而且 该人群中常见的易感等位基因在很大程度上仍不清楚。 几乎没有关于这一主题的文献,但对 非洲裔美国人特有的易感性在 识别处于危险中的非洲裔美国儿童。此外,不同寻常的 见于非裔美国人的一种糖尿病(1.5型),患者 存在于酮症酸中毒,但随后不需要胰岛素,可能有 一种独特的人类白细胞抗原类型。这种类型的身份可以用来劝告 家人。
英文摘要
Very few studies have typed HLA of African-Americans with diabetes, and predisposing alleles common in this population remain largely unknown. Almost no literature exists on this subject, and yet an understanding of susceptibility specific to the African-American population is essential in identifying at-risk African-American children. Furthermore, the unusual form of diabetes (type 1.5) seen in African Americans, in which patients present in ketoacidosis, but subsequently do not require insulin, may have a unique HLA type. Identification of this type could be used to counsel families.
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