MODEL PHOSPHOLIPID SURFACES VIA SELF ASSEMBLED MONOLAYER & SURFACE GRAFTING

该研究验证了一种“受控”磷脂的假设 由基材、聚二甲基硅氧烷聚合物和 磷脂酰胆碱酯可以通过使用顺序组装 嫁接化学。烯烃官能团三羟基硅烷是 与玻璃或二氧化硅反应，提供自组装的 反应性乙烯基单分子膜。金表面与烷基硫醇 还将被用来通过自组装形成富含乙烯的表面。 然后将氢化物官能化聚硅氧烷接枝到表面 使用可溶铂催化剂的乙烯基团。最后，剩余的 聚硅氧烷上的氢化物基团通过 铂催化的烯烃官能团加氢加氢反应 磷脂酰胆碱酯创造与血液接触的终极 一层。在每个阶段，确定表面元素组成 通过ESCA和SIMS光谱仪。

The study tests the hypothesis that a "controlled" phospholipid surfaceconsisting of a substrate, polydimethylsiloxane polymer and a phosphatidylcholine ester can be assembled by use of sequential grafting chemistries. Olefin functional trihydroxy silanes are reacted with glass or silicon dioxide to provide a self-assembled monolayer of reactive vinyl groups. Gold surfaces and alkane thiols will also be utilized to form a vinyl-rich surface by self-assembly. Afterwards hydride functional polysiloxanes are grafted to the surface vinyl groups using soluble platinum catalysts. Finally, the residual hydride groups on the polysiloxane are reacted again by platinum-catalyzed hydrosylilation of olefin functional phosphatidylcholine esters to create the ultimate blood-contacting layer. At each stage, the surface elemental composition is determined by ESCA and SIMS spectroscopies.