EPR OF METHEMOGLOBIN FORMATION IN RED CELLS W/ UNSTABLE HEMOGLOBIN

含血红蛋白S（HbS）的杂合子和纯合子 红细胞中高铁血红蛋白的浓度高于 不含突变蛋白。 已经为以下方面创造了条件： 已孵育红细胞的低温研究 37倍。 氧化血红蛋白浓度（S = 5/2，S = 5/2时为gimid） 1/2）与过氧化氢酶水平相关，并与红细胞压积相关。 正在调查的样品。 与正常红色进行比较 细胞 发现含HbS的细胞具有更高的 氧化血红蛋白的浓度比正常人高

Heterozygous as well as homozygous containing hemoglobin S (HbS) red cells contain higher concentrations of methemoglobin than those not containing the mutant protein. Conditions have been developed for low temperature investigations of red cells that have been incubated 37x. Oxidized hemoglobin concentrations (S = 5/2 and g imid for S = 1/2) are related to catalase levels and correlated with hematocrit of samples under investigation. Comparisons are made with normal red cells. It was found that HbS-containing cells have higher concentrations of oxidized hemoglobin than normals.