Does Fresh Frozen Plasma in Russells viper bite coagulopathy reduce the dose and duration of antivenom therapy?

该提案寻求资金，以在斯里兰卡进行一项用低剂量抗蛇毒血清治疗蛇咬伤凝血病的凝血因子替代试验。其目的是确定因子替代是否会导致凝血功能的快速恢复，允许更小剂量的抗蛇毒血清，从而降低大出血和抗蛇毒血清反应的潜在风险。这项研究将具有国际意义，因为全球蛇咬伤凝血病是发病和死亡的主要原因。

This proposal seeks funding to undertake a trial of clotting factor replacement with low dose antivenom therapy in snake bite coagulopathy in Sri Lanka. The aim is to determine if factor replacement will result in a rapid return of clotting function, allow a smaller dose of antivenom and therefore reduce the potential risk of major bleeding and reactions to antivenom. This study will have international implications because globally snakebite coagulopathy is a major cause of morbidity and death .