COLLECTION OF EEG/ERP PHENOTYPES ASSOCIATED WITH ALC

结论：酒精中毒是一种常见的、可遗传的、多基因的 疾病，但迄今为止，直接绘制基因图谱被证明是困难的。 了解酒精中毒的遗传起源可以提高预防 措施和治疗。 低电压阿尔法脑电图和P300 ERP有 都被证明与酗酒有关。 的目的 项目是收集这些和其他脑电图表型在400名成员， 一个平原美洲印第安部落。这些人来自几个非常 大家谱。我们已经有了精神病诊断和DNA 部落成员，并将完成这400人的数据集。 然后我们将能够执行传输和连接 酒精中毒的分析 本合同的目的 为EEG研究提供设施，招募受试者 并进行脑电图和心理测试（所有这些都在培训和 由NIAAA工作人员监督），收集和输入所有数据进行分析 是NIAA的工作人员

SUMMARY OF OBJECTIVES: Alcoholism is a common, heritable, multi-genic disease but it has so far proved difficult to map genes directly. Understanding the genetic origins of alcoholism may improve preventive measures and treatment. Low Voltage Alpha EEG and the P300 ERP have both been shown to be associated with alcoholism. The aim of this project is to collect these and other EEG phenotypes in 400 members of a Plains American Indian Tribe. These individuals come from several very large pedigrees. We already have psychiatric diagnoses and DNA on most tribal members and will complete this data set for the 400 individuals. We will then be in a position to perform transmission and linkage analysis for alcoholism in this tribe. The objectives of this contract are: to provide facilities for the EEG studies, to recruit the subjects and perform EEG and psychological testing (all under training and supervision by NIAAA staff), to collect and enter all data for analysis by NIAAA staff.