Undergraduate Training in Alcohol Research

描述(由申请人提供)：本提案的总体目标是 增加本科生从事高水平工作的机会， 由教师指导的关于酒精对大脑和行为影响的研究。 将为4至8名本科生提供研究支持 研究酗酒和酒精滥用的生物行为方法培训 酒精中毒，专注于影响发育的因素 成年人接触酒精或饮酒的后果。建议数 本科生酒精研究培训计划(UARTP)将允许 为合格的学生提供参与，否则他们可能没有时间或 参与的资源。支持本科生研究，作为 印第安纳大学普渡大学教育培训团 印第安纳波利斯(IUPUI)，仅限于本科生，即使研究 培训是我们最成功和最受欢迎的学习机制 对从事行为神经科学事业感兴趣的学生。我们 正在提出三个新的研究项目，为学生提供 参与综合研究的机会。这些项目，组成 这项提议的具体目的是：1)检验假设 酒精和新生儿隔离应激联合暴露的后果 在出生后早期会产生更严重的发育 大脑结构、神经化学和行为功能的改变 单独暴露在任何一种治疗下；2)检验这一假设 安非他明对脑刺激奖赏(BSR)的影响 偏爱和非偏爱大鼠品系的遗传选择 自愿饮酒的差异；以及3)检验假设 反复接触安非他明将导致神经适应性变化， 影响苯丙胺减少自愿饮酒的能力。这些 项目应为PI提供新的机会，使其能够利用自己的专业知识 发展动物模型研究的生产线，在发育和 酒精的精神药理作用。

DESCRIPTION (provided by applicant): The overall goal of this proposal is to increase the opportunities for undergraduate students to engage in high-level, faculty-mentored research into the effects of alcohol on brain and behavior. Four to eight undergraduate students will be provided support for research training in biobehavioral approaches to the study of alcohol abuse and alcoholism, concentrating on factors influencing either the developmental consequences of alcohol exposure or alcohol drinking in adults. The proposed Undergraduate Alcohol Research Training Program (UARTP) will allow expanded involvement for qualified students, who otherwise might not have the time or resources to participate. Support for undergraduate research, as part of the educational training mission at Indiana University Purdue University Indianapolis (IUPUI), is limited for undergraduates, even though research training is the most successful and preferred mechanism of learning for our students who are interested in pursuing careers in behavioral neuroscience. We are proposing three novel research projects to provide the students with opportunities to participate in integrative research. The projects, making up the specific aims of this proposal, are to 1) test the hypothesis that the consequences of combined exposure to alcohol and neonatal isolation stress during the early postnatal period will produce more severe developmental alterations in brain structure, neurochemistry, and behavioral function than exposure to either treatment alone; 2) test the hypothesis that the modulatory effects of amphetamine on brain stimulation reward (BSR) will differ between preferring and non-preferring lines of rats genetically selected for differences in voluntary alcohol drinking; and 3) test the hypothesis that repeated exposure to amphetamine will result in neuroadaptive changes that will affect the ability of amphetamine to reduce voluntary alcohol drinking. These projects should provide the PI new opportunities to use her expertise to develop productive lines of animal model research on the developmental and psychopharmacological effects of alcohol.