DIETARY ANTIOXIDANTS AND INFECTIOUS DISEASE

这项研究的目的是确定是否较高的饮食和补充摄入维生素C或E，或β -胡萝卜素与绝经后妇女较低的感染率有关。研究对象是普吉特海湾健康合作组织（GHC）的参与者，这是一家总部位于西雅图的大型健康维护组织，并且是骨折干预试验（FIT）的筛选者，这是一项最近被批准用于治疗骨质疏松症的阿仑膦酸钠的随机试验。本研究使用了1992年（FIT基线）至1997年研究期间GHC受试者记录的自动数据。此外，对医院和门诊病历表进行了医疗记录审查，以验证自动记录用于识别医院相关和门诊治疗感染的有效性。本研究获得了GHC人类受试者审查委员会和FIT出版物委员会的批准。作为该合同的一部分，正在进行的主要任务是建立一个数据集，以确定1517名研究对象的感染情况。数据将从以下GHC自动化数据库获得：药房（抗生素处方）、实验室（尿液分析、全血细胞计数、培养）和利用（来自出院摘要的ICD-9代码）。已经完成了对医院相关感染危险因素的调查分析。这些分析的手稿目前正在一本科学杂志上进行审查。通过与华盛顿大学药学院的教授合作，开发了一种利用自动药房记录识别抗生素治疗感染的新方法。已经为分析起草了一份手稿，通过与门诊医疗记录审查中确定的感染进行比较，验证了新方法，在随机样本的主题图表上进行。随后的分析将检验膳食抗氧化剂是否能降低住院病人和社区感染的风险。-抗氧化剂，感染，绝经后妇女-人类受试者

The purpose of this study is to determine whether higher dietary and supplemental intake of vitamins C or E, or beta-carotene is associated with lower rates of infections in postmenopausal women. The study subjects are enrollees of Group Health Cooperative of Puget Sound (GHC), a large Seattle-based health maintenance organization, and were screenees for the Fracture Intervention Trial (FIT), a randomized trial of alendronate, which was recently approved for treatment of osteoporosis. This study is using automated data from the subjects records at GHC for the study period from 1992 (FIT baseline) through 1997. In addition, medical record reviews of hospital and outpatient chart have been conducted to validate the use of the automated records for identifying hospital associated and outpatient treated infections. Approvals for this research were obtained from the GHC Human Subjects Review Committee and from the FIT Publications Committee. The primary task that is being conducted as part of this contract is the setting up of a dataset to identify the occurrence of infections in the 1,517 study subjects. Data will be obtained from the following GHC automated databases: pharmacy (antibiotic prescriptions), laboratory (urinalysis, complete blood count, cultures), and utilization (ICD-9 codes from hospital discharge summary). Analyses have been completed investigating risk factors for hospital associated infections. The manuscript for these analyses is currently under review at a scientific journal. Through collaboration with professors in the School of Pharmacy at the University of Washington, a new method for identifying antibiotic- treated infections was developed using the automated pharmacy records. A manuscript has been drafted for the analysis which validated the new method through a comparison with infections identified in outpatient medical record reviews, performed on a random sample of subjects charts. Subsequent analyses will examine whether dietary antioxidants reduced the risk for inpatient and community infections. - antioxidants, infections, postmenopausal women - Human Subjects