A HEPATOCYTE SPHEROID ENTRAPMENT BIOARTIFICIAL LIVER

描述（改编自研究者摘要）：肝衰竭是一种 在美国死亡的主要原因有一个肝脏援助的巨大需求 用于肝功能衰竭患者的临时支持的装置。Algenix正在开发一种 生物人工肝以满足这一关键需求。当第一代进入 临床试验，Algenix将开发第二代设备， 肝细胞球状体这些自组装的球状体表现出长期的生存能力， 在培养中增强肝功能。拟议的工作是进行一项研究， 设计参数并使用兔肝衰竭启动动物试验 模型 拟定商业应用： 本项目将为肝衰竭患者开发生物人工肝。

DESCRIPTION (Adapted from the Investigator's Abstract): Liver failure is a major cause of death in the U.S. There is a great need for a liver assist device for temporary support of liver failure patients. Algenix is developing a bioartificial liver to meet this critical need. As the first generation enters clinical trials, Algenix will develop a second generation device employing hepatocyte spheroids. These self-assembled spheroids exhibit long viability and enhanced liver functions in culture. The proposed work is to conduct a study of design parameters and to initiate animal trials using a rabbit liver failure model. PROPOSED COMMERCIAL APPLICATION: This project will develop a bioartificial liver for liver failure patients.