Variable compliance chamber to alter pulmonary impedance

描述（申请人的摘要）：可变柔量室（VCC） 建议在肺动脉高压期间维持接近正常的肺输入阻抗。 治疗肺部疾病。肺阻抗与总的 工作（稳定和脉动），右心脏必须泵反对，它是 改变（主要以顺应性降低的形式） 以及氧合辅助装置的植入;这种工作量的增加 会导致右心衰竭将开发一个VCC， 或者与植入式人工肺结合， 右心室的阻抗。VCC的一个重要应用 将允许患者进行移植或恢复治疗 患有原发性和继发性肺动脉高压。一期将 利用计算技术和台式实验来快速 VCC的发展和彻底的表征。完成时 第一阶段，将建造一个工作原型， 将进行研究，以验证VCC降低 肺阻抗谱，从而减少右心负荷，在 氧合辅助装置的应用。 拟议商业应用：不可用

DESCRIPTION (Applicant's Abstract): A variable compliance chamber (VCC) is proposed that will maintain near normal pulmonary input impedance during the treatment of pulmonary disease. Pulmonary impedance is related to the total work (steady and pulsatile) that the right heart must pump against, and it is altered (primarily in the form of decreased compliance) in pulmonary disease and in the implantation of oxygenation assist devices; this increase in work can lead to right-heart failure. A VCC will be developed that can be attached to the right-heart or combined with an implantable artificial lung to decrease the impedance seen by the right ventricle. An important application of the VCC will be to allow bridge-to-transplant or recovery treatment of patients suffering from primary and secondary pulmonary hypertension. Phase I will utilize computational techniques and bench-top experiments to allow rapid development of the VCC and thorough characterization. At the completion of phase I, a working prototype will be constructed and extensive bench-top studies will be performed to verify the ability of the VCC to decrease the pulmonary impedance spectrum, and thus decrease load on the right-heart, in the application of an oxygenation assist device. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE