课题基金 / 基金详情

HIGH RESOLUTION X-RAY FLUORESCENCE DETECTOR

HIGH RESOLUTION X-RAY FLUORESCENCE DETECTOR
高分辨率 X 射线荧光检测器
批准号:
6293934
负责人:
Ke Zhang
金额:
$10.08万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-03-02 至 2002-08-31

项目摘要

项目成果

Ke Zhang的其他基金

相关文献

中文摘要
翻译
描述(逐字摘自申请者摘要):已经演示过 该多层分析器阵列探测器在x射线荧光中具有优势 在高通量和稀金属条件下进行检测。以一种很好的拒绝 速度,大约25倍,以及相当大的实心角,亚毫米 专注力是可以常规获取的。然而,该项目的表现 探测器仍然滞后于光子通量和亮度的增加 第三代甚至第四代同步加速器源。有100多到 在第三代源上增加1000通量,这些源将允许 检测10微摩尔或几个百万分之几的金属浓度 射程。这将允许监测一些与生物相关的金属 活着。因此,我们建议开发x射线荧光探测器,利用合成的 多层对。主要和次要的两阶段拒绝 多层,预计废品率将超过200倍。 在吞吐量为20%的情况下,有效计数率的预期收益 在稀释系统上可以高达40倍。初步评估显示, 探测器可以在很宽的能量范围内调谐,覆盖大的固体 角度。第一阶段项目的主要目标是设计和制造一种 原型多层对探测器。探测仪的测试与评价 性能将有助于多层对分析器阵列的设计 探测器。第二阶段项目将把这样的探测器开发成产品。 建议的商业应用: 非常需要一种非常灵敏和高计数速率的x射线荧光探测器 这是正当的。该仪器将是x射线光谱分析和显微荧光的关键。 在高通量和稀薄情况下对生物系统进行成像。随着不断增加 在新的同步加速器光源下,该探测器将有更好的市场 比荧光电离室和固态探测器更有潜力 目前可用。
英文摘要
DESCRIPTION (Verbatim from the Applicant's Abstract): It has been demonstrated that multilayer analyzer array detector is advantageous in x-ray fluorescence detection under high flux and dilute metal conditions. With a good rejection rate, about 25 times, and reasonably large solid angle, sub-millimolar concentration can be routinely accessed. However, the performance of the detector is still lagging behind the photon flux and brightness increases at the third or even fourth generation synchrotron sources. With more than 100 to 1000 flux increases at the third generation source, these sources would permit detection of metal concentration in the order of 10 micro-Molar or several ppm range. This will allow the monitoring of some biologically relevant metals in vivo. Thus we propose to develop x-ray fluorescence detector using synthetic multilayer pairs. With two-stage rejection of primary and secondary multilayers, it is anticipated that the rejection rate will exceed 200 times. With a 20 percent throughput, the anticipated gain on the effective count rate can be as high as 40 times on dilute systems. Initial evaluation shows that the detector can be made tunable in a wide energy region and to cover a large solid angle. The major goal for the Phase I project is to design and fabricate a prototype multilayer pair detector. The test and evaluation of the detector performance will aid in the design of a multilayer pair analyzer array detector. Phase II project will develop such a detector to a product. PROPOSED COMMERCIAL APPLICATION: The need for a very sensitive and high count rate x-ray fluorescence detector is well justified. The instrument will be vital to x-ray spectroscopy and micro fluorescence imaging on biological systems under high flux and dilute situations. With ever increasing photon flux at the new synchrotron sources, the detector will have a better market potential than fluorescence ionization chambers and the solid state detectors which are currently available.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Development of a highly sensitive and specific POCT testing asthma triggering allergic IgE
  • 批准号:
    10600767
  • 项目类别:
  • 资助金额:
    $27.57万
  • 财政年份:
    2023
  • 负责人:
    Ke Zhang
  • 依托单位:
Development of a highly sensitive and specific POCT testing asthma triggering allergic IgE
  • 批准号:
    10817658
  • 项目类别:
  • 资助金额:
    $5.56万
  • 财政年份:
    2023
  • 负责人:
    Ke Zhang
  • 依托单位:
Molecular brush-conjugated antisense oligonucleotide as a pan-KRAS depletion agent
  • 批准号:
    10771051
  • 项目类别:
  • 资助金额:
    $5.5万
  • 财政年份:
    2022
  • 负责人:
    Ke Zhang
  • 依托单位:
Molecular brush-conjugated antisense oligonucleotide as a pan-KRAS depletion agent
  • 批准号:
    10544115
  • 项目类别:
  • 资助金额:
    $40.0万
  • 财政年份:
    2022
  • 负责人:
    Ke Zhang
  • 依托单位: