CONSOLIDATED BASIC CANCER RESEARCH PROGRAM

该计划涉及癌症的遗传学，生物学和病毒学。 新 我们对恶性肿瘤机制的理解的重大进展 转变是由于在该地区进行的调查， 威斯塔研究所。 特异性癌基因在恶性肿瘤发病中的作用 人类白血病和淋巴瘤的发病机制已得到评估 它们的激活已经被确定。 此外，最近， 已经有可能确定T细胞α链的基因 受体可能在人T细胞癌基因激活中起重要作用 白血病 与造血系统恶性肿瘤有关的新癌基因已经被发现， 鉴定、克隆和鉴定。 此外，在核领域取得了新的突破， 转移到受精卵中。 在这方面极高的成功率 一种实验为我们理解哺乳动物的能力开辟了新的途径 发展和研究细胞质核因子的作用 在早期胚胎发育中。

This program concerns the genetics, biology and virology of cancer. New major developments in our understanding of the mechanisms of malignant transformation have resulted from the investigations carried out at The Wistar Institute. The role of specific oncogenes in the pathogenesis of leukemias and lymphomas in man has been assessed and the mechanisms of their activation have been determined. In addition, very recently it has been possible to establish that the gene for the alpha chain of the T cell receptor may have an important role in oncogene activation in human T cell leukemia. New oncogenes involved in hematopoietic malignancies have been identified, cloned and characterized. In addition new breakthroughs have been achieved in the area of nuclear transfer into fertilized eggs. The extremely high rate of success in this type of experiment opens new avenues in our ability to understand mammalian development and to investigate the role of cytoplasmic nuclear factors during early embryogenesis.