CORE--GENETICALLY MODIFIED MICE

转基因小鼠共享服务为 癌症中心和其他大学研究人员获得转基因动物 技术以一种高效、节约成本的方式。这个核心允许 调查人员使用转基因小鼠，从1997年11月开始， 服务部门将能够协助调查人员生产新的鼠标 基因打靶在胚胎干细胞中的突变体。这项服务还包括 将为ES细胞研究提供基因打靶技术。在.期间 去年一年半以来，通过汇编信息扩大了服务范围 在其他可用的分子改变的小鼠身上。共享服务 工作人员协助获取老鼠，并对其进行维护和筛选。 目标是帮助调查人员确定或开发要解决的模型 他们特定的癌症研究。自从发展或建立殖民地以来 这些特殊的鼠标非常昂贵，共享服务集中在 这些努力，从而降低了一些巨大的启动成本 在开发动物模型时。重要的是，这个设施允许 以前未使用过鼠标模型的个人将受到指导 在他们的使用中。随着越来越多的调查人员开始意识到 在这些系统中，这项服务的使用量每年都在增加， 存在的头三年。

The Genetically Modified Mice Shared Service provides members of the Cancer Center and other University researchers access to transgenic animal technology in a n efficient cost-saving manner. This core allows investigators to use transgenic mice and, beginning in November 1997, the service will be able to assist investigators in producing new mouse mutants by gene targeting in embryonic stem (ES) cells. The service also will provide gene targeting technology for ES cell research. During the last year and a half, services have been expanded by compiling information on other molecularly altered mice that are available. The shared service personnel assist in obtaining the mice and maintaining and screening them. The goal is to help investigators identify or develop models to address their specific cancer research. Since developing or establishing colonies of these special mice is very expensive, the shared service centralizes these efforts, thus reducing some of the large start-up costs that occur when developing animal models. Importantly, this facility allows individuals who have not previously worked with mouse models to be guided in their use. As more investigators have come to realize the power of these systems, use of this service has increased each year, during the first three years of existence.