Drug glucuronidation - An integrated approach

药物在体内通过代谢过程被分解。代谢是一个重要的解毒和消除机制，并决定剂量率长期给药。许多药物是通过葡萄糖醛酸化反应代谢的。我们将以一种综合的方式描述葡萄糖醛酸化反应的各种组成部分，以便了解和预测影响个体代谢药物和其他化学物质能力的因素。

Drugs are broken down in the body by the process of metabolism. Metabolism is important as both a detoxification and elimination mechanism, and determines dose rate for chronically administered drugs. Many drugs are metabolised by a reaction called glucuronidation. We will characterise the various components of the glucuronidation reaction in an integrated manner in order to understand and predict factors that influence an individual's capacity to metabolise drugs and other chemicals.