低钾血症患者钾稳态的评估-猫眼课题宝

低钾血症患者钾稳态的评估

批准号：

6306186

负责人：

MARGARET J BIA

金额：

$3.45万

依托单位：

YALE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

1999

资助国家：

美国

项目状态：

已结题

起止时间：

1999-12-01 至 2000-11-30

来源：

https://reporter.nih.gov/project-details/6306186

关键词：

Bartter's syndrome body fluid balance therapy bone density bone metabolism calcium clinical research disease /disorder etiology diuretics gene mutation homeostasis human subject hypokalemia kidney metabolism magnesium metal metabolism potassium sodium

中文摘要

翻译

本方案的目的是评价无明显原因的低钾血症患者的原因和治疗，并描述遗传学确诊的Gitleman综合征或Bartter综合征患者亲属的肾脏钠、钾、镁和钙处理。具体来说，我们想测试的假设，杂合子亲属Gitelman的或巴特的突变更容易受到利尿剂引起的低钾血症。我们也在测试它们是否比野生型亲属有更低的血压和/或更高的骨密度。

英文摘要

The aims of this protocol are to evaluate the cause and treatment of hypokalemia in patients who maintain this problem without an obvious cause and to characterize the renal handling of sodium, potassium, magnesium and calcium in relatives of patients with genetically confirmed Gitleman's or Bartter's Syndrome. Specifically, we would like to test the hypothesis that heterozygote relatives for Gitelman's or Bartter's mutations are more susceptible diuretic-induced hypokalemia. We are also testing whether they have a lower blood pressure and/or higher bone density than their wild type relatives.

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