DsbA foldases from multidrug resistant pathogens as targets for new antimicrobials

引起常见人类感染的细菌，如膀胱炎和腹泻，现在对许多抗生素具有耐药性。如果不采取行动，到2050年，抗生素耐药性感染每年导致的死亡人数将超过癌症。该项目旨在通过描述旨在解除多药耐药病原体的有希望的新细菌靶点和抑制剂的特征，来解决这一全球公共卫生危机。从长远来看，这项工作可以提供迫切需要的新的感染治疗方法。

Bacteria that cause common human infections, such as cystitis and diarrhoea, are now resistant to many antibiotics. If no action is taken, by 2050 antibiotic resistant infections will kill more people each year than cancer. This project aims to address this global public health crisis by characterising promising new bacterial targets and inhibitors designed to disarm multidrug resistant pathogens. Longer term this work could provide new infection therapies that are urgently needed.