CORE--GENE TARGETED MOUSE FACILITY

这个PPG的中心主题是基因工程小鼠。这个核心是基因靶向小鼠设施，位于洛克菲勒大学。该设施将提供将用于每个子项目的基因=目标小鼠。蒙贝尔茨博士在洛克菲勒大学的实验室里已经培育出了大多数这样的老鼠。新的菌株将在这个核心中发育和沉积。由于在其他机构复制这些小鼠品系的成本很高，而且质量控制必须严格，我们选择使用单一设施，通过该设施将小鼠分发给每个组。由于各个实验室的地理位置接近，集中培育基因靶向小鼠不会造成障碍。

A central theme in this PPG is the genetically engineered mouse. This Core is the Gene-Targeted Mouse Facility, located at The Rockefeller University. The facility will provide the gene=targeted mice that will be used in each of the subprojects. Most of these mice have already been developed by Dr. Mombaerts in his laboratory at The Rockefeller University. New strains will be developed and deposited in this core. Because duplicating these lines of mice at other institutions is costly and because quality control must be stringent, we have elected to utilize a single facility through which mice will be distribute to each of the groups. Centralized breeding of the gene-targeted mice will not pose a hurdle because of the geographical proximity of the various laboratories.