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CORE--CELL AND ANIMAL MODEL

CORE--CELL AND ANIMAL MODEL
核心--细胞和动物模型
批准号：
6284079
负责人：
RANDALL H KRAMER
金额：
$6.07万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-06-01 至 2005-11-30
来源：
https://reporter.nih.gov/project-details/6284079
关键词：
biomedical facility cell line disease /disorder model keratinocyte laboratory mouse mouth neoplasms neoplastic growth squamous cell carcinoma tissue /cell culture transfection

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中文摘要
翻译
该计划项目的几个单独提出的研究计划的重要部分依赖于口腔鳞状细胞癌细胞和口腔癌发生和进展的动物模型的使用。细胞和动物模型核心将提供这些研究所需的材料。恶性角质形成细胞系和正常角质形成细胞系都可用，它们是拟议研究的基本工具。此外，Core B还将协助利用逆转录病毒载体将细胞转入细胞，并进行肿瘤侵袭和迁移分析。核心设施的另一项重要任务是提供几种不同的口腔癌动物模型，用于研究口腔癌的发展、进展和侵袭/转移。
英文摘要
Important parts of several of the individually proposed research programs of this Program Project depend on the use of human oral squamous cell carcinoma cells and animal models for oral cancer development and progression. The Cell and Animal Model Core will provide the material required for these studies. Both malignant and normal keratinocyte cell lines, which are essential tools for the proposed studies are available. In addition, Core B will assist in the transfection of cells using retroviral vectors and in the performance of tumor invasion and migration assays. Another important task of the Core Facility will to make available several different animal models of oral cancer for the study of development, progression and invasion/metastasis.
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