Supplementary support for the research programme funded by the CI Grant ST/G008248/1, FELIS( Free Electron Laser integration for SNOM) project.

食道癌是西方世界上升最快的癌症发病率。诊断尤其困难，因为当大多数患者出现症状就诊时，癌症已经扩散，很难通过手术成功治疗。然而，有一种先前存在的良性疾病，称为巴雷特食道，可以通过胃肠内窥镜进行监测。一小部分Barrett‘s食道病患者会患上食道癌。如果这些患者能够及早被发现，那么就有可能成功地治疗他们。这项研究将在达累斯伯里爱丽丝加速器的红外自由电子激光器上安装一种名为SNOM的高性能显微镜。这种显微镜将使获得巴雷特食道患者组织的高分辨率化学图像成为可能，这将使诊断患者是否会继续发展为食道癌成为可能。

Oesophageal cancer is the fastest rising incidence of cancer in the western world. It is particularly difficult to diagnose with the result that by the time most patients visit their doctor with symptoms the cancer has spread and it is difficult to treat successfully by surgery. However there is a pre-existing benign condition called Barret's oesophagus which can be monitored by gastrointestinal endoscopy. A small percentage of patients with Barrett's oesophagus will develop oesophageal cancer. If these patients can be identified early then it is possible to treat them successfully. This research will install a high performance microscope called a SNOM on the infrared free electron laser on the ALICE accelerator at Daresbury. This microscope will make it possible to obtain high resolution chemical images of tissue from patients with Barrett's oesophagus that will make it possible to diagnose whether the patients will go on to develop oesophageal cancer.