MEDICAL SCIENCES CAMPUS RESEARCH DEVELOPMENT-SUPPLEMENT

目前RCMI计划在UPR医学科学校园的目标 是继续发展高质量的生物医学研究， 在前五年取得的进展的基础上， 经费 为了实现这一目标，该方案着重于发展 基础设施和提供研究支持服务，以及 增加活跃的研究人员的数量，包括教师， 研究助理、研究助理和技术人员。 有限 一些活跃的研究人员，以及训练有素的技术人员， 人员，已被确定为最重要的因素之一 限制了目前的研究生产力。 研究的改进 基础设施和环境提高了我们解决这一问题的能力 问题立即。 重点研究领域已选定为 因为现有的或潜在的优势。 的范围 该计划还扩大到包括临床和生物社会 research. 该方案由两个主要部分组成：经常方案和 艾滋病项目。 在经常部分中，有三个基本的 研究活动，其重点是增加教师的数量， 研究助理和技术人员在以下领域工作： 神经生物学、细胞生理学和药理学以及分子生物学。 临床研究活动，癌症细胞发生实验室，也是 列入常规方案。 还为继续开展一项重大研究提供了支助。 支持设施：中央电子显微镜单位。 结束七 半年后，这是流式细胞术资助的最后一年， 实验室 该设施以及其他专业实验室和 在第一个周期中获得RCMI支持的服务，现在正在 由机构资金和/或收费产生的资金维持 系统或正在寻求支持。 目前计划的艾滋病部分扩大了1989年开始的努力 在我们最初的RCMI赠款的艾滋病补充下， 艾滋病的临床研究 两大活动由原来的 补充剂仍然有效。 其中之一代表了一种努力， 艾滋病临床研究，通过建立多学科研究 诊所，为受控制的门诊患者提供协调的访问 人口、适当的病历管理和必要的 实验室测试 第二项活动支持一项研究计划， 天然产品与潜在的抗艾滋病毒行动，通过提供 建立最先进的抗艾滋病毒检测系统所需的资源 在研究人员的实验室里。 还通过一个 艾滋病补充申请，以扩大抗艾滋病毒筛查计划 1991年发起，并支持一个新的研究项目：HIV-1的作用 env基因变异与垂直传递的向性 这个项目 是年轻研究人员之间的合作努力， 分子生物学/病毒学和细胞生物学领域的专业知识 免疫学 该项目将加强我们正在进行的努力， 分子生物学的研究。

The goal of the current RCMI Program on the UPR Medical Sciences Campus is to continue the development of high quality biomedical research, building on the progress which was made during the first five years of funding. To achieve this goal the Program has focused on developing infrastructure and providing research support services, as well as to increase the number of active research personnel, including faculty, research associates, research assistants and technicians. The limited number of active researchers, as well as highly trained technical personnel, has been identified as one of the most important factors limiting research productivity at present. Improvements in the research infrastructure and environment have improved our ability to address this problem immediately. Key research areas have been selected for development because of existing or potential strengths. the scope of the Program has also been expanded to include clinical and biosocial research. The Program consists of two major components: the regular program and the AIDS program. Within the regular component there are three basic research activities, whose focus is to increase the number of faculty, research associates and technical personnel working in the areas of neurobiology, cell physiology and pharmacology, and molecular biology. A clinical research activity, the cancer cytogenesis laboratory, is also included in the regular program. Support is also provided to continue development of a major research support facility: the Central Electron Microscopy Unit. After seven and a half years, this was the final year of funding for the Flow Cytometry Laboratory. This facility, as well as other specialized laboratories and services that received RCMI support during first cycle, are now being sustained with institutional funds and/or funds generated by charge-back systems, or are seeking support. The AIDS component of the current program expands efforts, begun in 1989 under an AIDS supplement to our original RCMI grant, to develop basic and clinical research in AIDS. Two major activities from the original supplement remain active. One of these represents an effort to expand clinical research in AIDS, by establishing a multidisciplinary Research Clinic, which provides coordinated access to a controlled outpatient population, appropriate management of patient records and necessary laboratory testing. The second activity supports a research program in natural products with potential anti-HIV actions, by providing the resources needed to establish a state-of-the-art anti-HIV assay system in the researcher's laboratory. Funds were also obtained, through an AIDS supplemental Application, to expand the anti-HIV Screening Program initiated in 1991 and to support a new research project: Role of HIV-1 env Gene variation and Tropism in Vertical Transmission. This project is a collaborative effort between young investigators, with complementary expertise in the areas of molecular biology/virology and cellular immunology. This project will strengthen our ongoing efforts to develop research in molecular biology.