RESEARCH CENTER FOR STUDY OF GENE STRUCTURE AND FUNCTION

亨特学院基因结构和功能研究中心 将继续专注于高质量的研究和 招募少数族裔科学家和博士生 进取号。亨特可以为这个国家做出特殊贡献 承诺。我们稳步改善了我们的研究活动；一些 我们的实验室中有一半是国际公认的。我们的学生团体是 非常多样化，反映了纽约的种族和民族多样性 城市本身。我们最近聘请了更多的少数族裔教员，并希望 继续这个。我们的要求包括在大学里招聘新教师的资金 对建设有机构承诺的直接成本预算 他们的实验室。还要求为少数族裔研究提供资金。 帮助我们的研究工作并使我们的员工多样化的同事。一位少校 我们建议的重点是减少我们对RCMI资金的依赖 随着时间的推移。因此，教职员工职位的资金和 核心设施经理的结构是这样的，他们来自 RCMI的预算将在赠款的后几年逐步取消。在这 在框架内，要求全职支付不同时期的薪金 时间，生物分子计算和图形学的管理者 生物成像设施和质谱学设施。 后两种观点在《世界卫生组织 生物系和化学系。生物心理学研究 主动性也作了描述。集体研究计划 确定招聘教师的领域，并举例说明如何招聘 核心设施提供基本服务。我们申请资金用于 对这些服务的技术支持，这些服务在赠款期间逐步取消 句号。这些设施的供应品是按年申请的。 递减的数量。这项新提案包含了几个主要的要求 仪器仪表。预算的结构使当前和未来 机构捐款被清楚地描绘出来。我们继续看到 RCMI计划之外的新支持来源。新的艾滋病毒和艾滋病- 并介绍了相关项目。这些领域包括三个领域：毒品 环丙沙星的合成及其作用机理研究、激活和控制 来自HIV LTR的转录，以及可能的应激效应 艾滋病痴呆症的生理学。化学研究倡议还具有 对HIV/AIDS的临床意义的研究，以及对 癌症研究(丝裂霉素C的衍生物)。

The Center for Study of Gene Structure and Function at Hunter College will continue to focus on conducting research of high quality and recruiting minority scientists and Ph.D. candidates into this enterprise. Hunter can make a special contribution to this National undertaking. We have steadily improved our research activities; some of our laboratories are internationally recognized. Our student body is remarkably diverse, reflecting the racial and ethnic variety of New York City itself. We have recently hired more minority faculty and wish to continue this. Our request includes funds for hiring new faculty in the direct costs budget with an institutional commitment to the construction of their laboratories. Also requested are funds for minority research associates who help our research effort and diversify our staff. A major emphasis in our proposal is to reduce our dependence on RCMI funding over time. Therefore, funding of the positions for faculty and managers of core facilities is structured so that their support from the RCMI budget will be phased out in the later years of the grant. In this framework, full time salaries are requested, for different periods of time, for managers of the Biomolecular Computation and Graphics Facility, the Bio-imaging Facility, and the Mass Spectroscopy Facility. The last two are specially justified in new Research Initiatives of the Departments of Biology and Chemistry. A Biopsychology Research Initiative is also described. The Research Initiatives collectively define areas for faculty recruitment, as well as provide examples of how core facilities supply essential services. We request funds for technical support for these services which are phased out over the grant period. Supplies for these facilities are requested, in annually decreasing amounts. This new proposal contains few major requests for instrumentation. The budget is structured so that current and future institutional contributions are clearly delineated. We continue to see new sources of support outside of the RCMI program. New HIV and AIDS- related projects are presented. These comprise three areas: drug synthesis and mechanism-of-action studies, activation and control of transcription from the HIV LTR, and possible stress effects in the physiology of AIDS dementia. The Chemistry Research Initiative also has clinical - significance for HIV/AIDS in studies of pentamidine, and for cancer research (derivatives of Mitomycin C).