PHYSIOLOGICAL BASES OF OTOTRAUMATIC INSULT

说明：拟进行的研究集中于 耳蜗-传出系统对噪声的易感性及耳聋现象 “声音条件反射。”提出了几个假设来确定 耳朵的敏感度可以通过声音进行实验控制 条件反射，如果耳蜗传出系统参与声音条件反射 以及这一过程中是否涉及听觉或系统因素。在……里面 此外，防止声音过度暴露的分子基础将是 探索过了。实验中使用的功能测量是2f1-f2 DPOAE 以及通过呈现给对立面的纯音调来改变它 耳朵。DPOAE在双耳刺激下的变化被认为是一种衡量 “传出力量”，这似乎在不同的动物和人类之间有所不同。 提出了三个假设。在第一部中，清醒的兔子将被用作 受试者确定传出系统是否在声音中起作用 条件反射，这种影响是否是耳朵特有的，以及是否有其他系统性的 这其中涉及到各种因素。第二种假说测试的是“声音”的程度 条件作用“在易感性不同的小鼠身上很明显 噪音引起的听力损失。第三种假设测试的是易感性 听力损失或对其的预防与特定的分子有关 在耳蜗里。

Description: The proposed studies focus on the contribution of the cochlear-efferent system in the susceptibility to noise and the phenomenon of "sound conditioning." Several hypotheses are proposed to determine whether the susceptibility of the ear can be experimentally manipulated through sound conditioning, if the cochlear-efferent system is involved in sound conditioning and whether auditory or systemic factors are involved in the process. In addition, the molecular bases of protection from sound-overexposure will be explored. The functional measure employed in the experiment is the 2f1-f2 DPOAE and its alteration by presentation of a pure tone presented to the opposite ear. The change in DPOAE with binaural stimulation is proposed as a measure of "efferent strength," which appears to vary among individual animals and humans. Three hypotheses are proposed. In the first, awake rabbits will be used as subjects to determine if the efferent system plays a role in 'sound conditioning', whether the effect is ear-specific and whether other systemic factors are involved. The second hypothesis tests the extent to which "sound conditioning" is apparent in mice that have varying susceptibility to noise-induced hearing loss. The third hypothesis tests whether susceptibility to hearing loss or the prevention from it is associated with specific molecules in the cochlea.