ATTRIBUTES OF SICKLE CELL PAIN IN INFANTS AND YOUNG CHILDREN

该提案将对以下方面进行全面评估： 婴幼儿血管闭塞性疼痛的特点 镰状细胞病（SCD）的儿童。这将是第一项研究， 具体描述疼痛强度和持续时间， 门诊和住院治疗的疼痛发作， 设计，在一个庞大的人口的婴儿和幼儿。此外，本发明还提供了一种方法， 这项研究将探讨其他几个方面的疼痛经验， 这些患者以前没有进行过任何深入的研究， 包括可能的诱发因素，对疼痛的行为反应， 镇痛剂的用法和疗效。与项目I合作，我们将 全面检查血液学和 实验室变量和这些婴儿疼痛的发作和频率 和年幼的孩子。我们亦会就 有效性和可靠性的疼痛评估工具，在这方面， 患者人群，并检查疼痛频率之间的关系 与婴儿气质或父母应对方式的关系。 虽然这些研究中的每一项都可以单独进行， 这些研究在相同患者人群中的组合， 前瞻性的基础上，将产生丰富的比较信息， 将使我们能够评估一套全面的 预测疼痛风险的临床和实验室因素 发作，SCD最常见和使人衰弱的并发症。与 从上述研究中获得的知识，我们将能够更好地 减轻这些病人的痛苦和痛苦， 疼痛评估和管理。更重要的是，我们将能够 在主要器官损伤发生之前，在早期确定那些 经常出现临床并发症的儿童， SCD创新疗法试验的候选人。

This proposal will perform a comprehensive assessment of the characteristics of the vaso-occlusive pain experience in infants and young children with Sickle Cell Disease (SCD). It will be the first study to specifically characterize the pain intensity and duration of both outpatient and hospital-treated painful episodes, with a prospective design, in a large population of infants and young children. In addition, this study will examine several other facets of the pain experience in these patients that have not been previously studied in any depth, including possible precipitating factors, behavioral response to pain, and analgesic usage and efficacy. In collaboration with Project I, we will comprehensively examine the relationship between hematologic and laboratory variables and the onset and frequency of pain in these infants and young children. We will also conduct the first detailed study of the validity and reliability of available pain assessment instruments in this patient population, and examine the relationship between pain frequency and infant temperament or parental coping style. While each one of these studies could be done in isolation, the combination of these studies in the same patient population, on a prospective basis, will yield a wealth of comparative information that will allow us to assess the relative importance of a comprehensive set of clinical and laboratory factors that predict the risk for painful episodes, the most frequent and debilitating complication of SCD. With the knowledge obtained from the above studies, we will be better able to alleviate the pain and suffering of these patients through more effective pain assessment and management. More importantly, we will be able to identify at an early age, prior to the onset of major organ damage, those children with frequent clinical complications who could be appropriate candidates for trials of innovate therapies for SCD.