SOUTHWEST REGIONAL PRIMATE RESEARCH CENTER

这项建议的目标是建立西南地区灵长类研究中心。这个新中心将位于西南生物医学研究基金会(SFBR)占地397英亩的园区内。它将由SFBR和附近的圣安东尼奥德克萨斯大学健康科学中心的核心科学家、核心兽医和附属科学家组成。SFBR将向灵长类中心分配其拥有的所有狒狒(目前为3230只)、它拥有或管理的所有黑猩猩(目前为242只)以及它拥有的所有其他非人类灵长类动物(目前为163只)。它还将分配给灵长类中心独家使用188,654平方英尺(总面积)的空间，用于动物、程序室、办公室和实验室，以及一个黑猩猩游乐场(9000平方英尺)和两个6英亩的禽舍。该中心将为主要位于美国西南部的研究人员提供服务，并将提供无与伦比的非人类灵长类资源的组合，以及支持合作研究活动的专业科学资源、能力和设施。独特的动物资源将包括世界上最大的狒狒繁殖群体，有史以来为非人类灵长类物种建立的最大和最深的系谱，用于基因治疗研究的非人类家族性高胆固醇血症灵长类动物模型，以及用于衰老研究的纯种老年狒狒群体。灵长类中心的科学家和兽医将被组织成四个工作组：实验室动物医学、生理学和医学、病毒学和免疫学以及遗传学。每个小组提出服务组件、模型和技术开发组件，并进行试点研究。该中心的研究重点将包括非人类灵长类疾病和福祉，非人类灵长类动物非传染性疾病的生理学和治疗模型，传染病的机制和预防和治疗策略，以及慢性和传染性疾病的易感性遗传学。这些领域的研究计划将通过招募在基因治疗、生殖内分泌学、神经内分泌学、老龄化和新出现的抗生素耐药性方面具有专业知识的核心科学家来加强。为服务于研究界、学生和博士后研究员以及公众，提出了一个全面的培训和外展计划。

The objective of this proposal is to establish the Southwest Regional Primate Research Center. This new Center will be located on the 397-acre campus of the Southwest Foundation for Biomedical Research (SFBR). It will be staffed by Core Scientists, Core Veterinarians, and Affiliate Scientists based at SFBR and the nearby University of Texas Health Science Center at San Antonio. SFBR will assign to the Primate Center, for its exclusive use, all baboons that it owns (currently 3,230), all chimpanzees that it owns or manages (currently 242), and all other nonhuman primates that it owns (currently 163). It also will assign to the exclusive use of the Primate Center188,654 square feet (gross) of space for animals, procedure rooms, offices, and laboratories, as well as a chimpanzee playground (9,000 square feet) and two 6-acre corrals for baboons. The Center will serve investigators located primarily in the southwestern United States, and will provide an unparalleled combination of nonhuman primate resources, as well as specialized scientific resources, capabilities, and facilities for the support of collaborative research activities. Unique animal resources will include the largest baboon breeding colony in the world, the largest and deepest pedigree ever established for a nonhuman primate species, a nonhuman primate model of familial hypercholesterolemia for gene therapy research, and a pedigreed geriatric baboon colony for research on aging. Primate Center scientists and veterinarians will be organized into four working groups: Laboratory Animal Medicine, Physiology and Medicine, Virology and Immunology, and Genetics. Each group proposes service components, model and technology development components, and pilot studies. Research foci at the Center will include nonhuman primate diseases and well-being, nonhuman primate models for the physiology and treatment of noninfectious human diseases, the mechanisms involved in infectious diseases and strategies for preventing and treating them, and the genetics of susceptibility to chronic and infectious diseases. Research programs in these areas will be strengthened by recruitment of Core Scientists with expertise in gene therapy, reproductive endocrinology, neuroendocrinology, aging, and emerging resistance to antibiotics. A comprehensive training and outreach program is proposed to serve the research community, students and postdoctoral fellows, and the public.