PROPIONATE UTILIZATION, GLUCONEOGENESIS, & PYRUVATE RECYCLING IN HUMAN LIVER

班萨尔博士最近搬到了宾夕法尼亚大学。 在几个正在准备的手稿完成后，这 传票将被删除。我们已经实施了一种三维 4.7T系统上的23Na MQ成像序列。这种梯度回波 成像序列能够采集交错的SQ和TQ 23Na 回声时间非常短(2.5-5毫秒)的图像。我们用过这个 成像序列研究缺血对兔肾脏的影响。 交错的SQ和TQ滤波的23Na图像在之前和 牺牲动物后，的数据点超过了32 x 32 x 50 x 50 x 100 mm3的视场和4 ms的回声时间。总图像数据 收集时间为4h。SQ图像表示4-5个折叠 延髓区域的信号强度比 大脑皮层。正常肾脏的TQ滤波图像没有显示任何 由于该技术灵敏度较低，因此信号强度较高。 然而，在死亡时，肾皮质在TQ中变得清晰可见。 在不显著增加信号强度的情况下对图像进行滤波 延髓区域。这主要是因为大脑皮质区域 肾脏有很大的细胞内空间，而髓质区 主要是腔内和血管内。这些图像清楚地表明 MQ滤波信号强度的增加可能是一个非常好的 细胞损伤的标志物。(服务3)报告期： (09/01/97-08/31/98)

Dr. Bansal has recently moved to the University of Pennsylvania. Upon completion of several manuscripts which are in preparation, this subpoject will be deleted. We have implemented a three-dimensional 23Na MQ imaging sequence on the 4.7T system. This gradient echo imaging sequence is capable of collecting interleaved SQ and TQ 23Na images with very short echo times (2.5-5 ms). We have used this imaging sequence to study the effect of ischemia in rabbit kidney. Interleaved SQ and TQ filtered 23Na images were collected before and after sacrificing the animal with 32 x 32 x 64 data points over a 50 x 50 x 100 mm3 field of view and 4 ms echo time. The total image data collection time was 4 hours. The SQ image indicates a 4-5 fold greater signal intensity in the medullary region as compared to the cortex. The TQ filtered image of the normal kidney did not show any signal intensity due to the low sensitivity of the technique. However, on death, the renal cortex became clearly visible in the TQ filtered image without any substantial increase in signal intensity in the medullary region. This is mainly because the cortical region of the kidney has a large intracellular space while the medullary region is mainly intraluminal and vascular. These images clearly suggest that increase in MQ filtered signal intensity may be a very good marker of cellular injury. (Service 3) REPORT PERIOD: (09/01/97-08/31/98)