MAMMARY CARCINOGENESIS IN RATS--HORMONAL PREVENTION

描述：(根据申请者的描述改编)第一个完整学期 女性在青春期怀孕可能会永久性地降低她们的 罹患乳腺癌的风险。在目前的提案中， 调查人员将彻底分析与产次相关的原因 对大鼠乳腺癌发展的耐受性，并检测 奋乃静保护作用的机制 会导致一过性催乳素血症。该提案包括四个具体目标： [1]产后大鼠对MNU诱导乳房耐受的研究 致癌，[2]难治性是否永久性，[3] 表征奋乃静引起的耐受性，并[4]其机制 在奋乃静诱导的顽固性。长期目标是 生成可用于制定战略的实验范例 用于预防人类乳腺癌，而不会有明显的改变 生活质量。

DESCRIPTION: (Adapted from Applicant's description) First full term pregnancy during the teen age years in women can permanently reduce their risk for developing breast cancer. In the current proposal, the investigator will thoroughly analyze the causes of parity-related refractoriness to mammary cancer development in rats, and examine the mechanism underlying the protection effect of perphenazine, a drug which causes transient prolactinemia. The proposal includes four Specific Aims: [1] Studies of the refractoriness of parous rats to MNU-induced mammary carcinogenesis, [2] whether the refractoriness is permanent, [3] characterize the perphenazine-induced refractoriness, and [4] the mechanism underlying the perphenazine-induced refractoriness. The long-term goal is to generate an experimental paradigm that can be used to develop strategies for the prevention of human breast cancer without significant alterations in the quality of life.