DNA & PROTEIN SEQUENCE ANALYSIS CONSULTING & SOFTWARE DVMT: BIOINFORMATICS, WWW

在加州大学旧金山分校的序列分析咨询服务 向100多个实验室提供序列数据库和软件，其中包括1200多个实验室 加州大学旧金山分校的人们，我们拥有听力软件的独特优势 直接从研究人员那里获得发展优先事项。多个领域 科学家认为需要改进的是用户界面和 自动化。许多生物信息学项目尚未利用 在WWW、Python、Java和CGI等领域取得的进展 帮助改进和简化用户界面。随着经济的快速增长 通过DNA测序和DNA显微技术的进步进行数据生产 阵列技术，对开发自动化有很大的兴趣 对原始数据的分析。用于序列比对的软件工具和 结构同源建模必须随着由产生的新数据而发展 例如基因组计划和DNA阵列等技术。我们 设计了利用这些新技术的程序 使信息学家/科学家拥有更友好的用户界面和 高效的工作环境。我们有生产中的工具来帮助 使初级序列数据的数据处理流水线自动化 对这些结果的管理。我们正在设计一个Perl和Python 对结构感兴趣的分子生物学家申请制作 与浏览一样简单的Unix序列分析和同源建模工具 网络。计算机图形学实验室及其资源提供 这项跨学科工作的独特背景。

At the Sequence Analysis Consulting Services of UCSF, serving sequence databases and software to over 100 labs including over 1200 people at UCSF, we have the unique advantage of hearing software development priorities directly from the researchers. Areas many scientists feel requires much improvement is user interface and automation. Many bioinformatics programs have yet to take advantage of advances made in areas such as the WWW, Python, Java and the CGI to help improve and simplify the user interface. With the rapid increase in data production through advances in DNA sequencing and DNA micro array technology, there is great interest in developing automated analysis of primary data. Software tools for sequence alignments and structure homology modeling must evolve with the new data produced by efforts such as Genome projects and technologies like DNA arrays. We have designed programs that take advantage of these new technologies to enable the informaticist/scientist to have a more user-friendly and efficient working environment. We have tools in production to help automate the data processing pipeline for primary sequence data and management of these results. We are designing a Perl and Python application for molecular biologists interested in structure to make UNIX sequence analysis and homology modeling tools as easy as browsing the Web. The Computer Graphics Laboratory and its resources offer a unique context for this interdisciplinary work.