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INHIBITION OF LDL OXIDATION BY ISOFLAVONOIDS

INHIBITION OF LDL OXIDATION BY ISOFLAVONOIDS
异黄酮类化合物抑制 LDL 氧化
批准号：
6307883
负责人：
RAKESH P. PATEL
金额：
$1.13万
依托单位：
MEDICAL COLLEGE OF WISCONSIN
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-03-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6307883
关键词：
bioengineering /biomedical engineering biological products biomaterials biomedical resource

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中文摘要
翻译
许多研究表明，氧化改性低密度 脂蛋白（LDL）代表了发展中的关键步骤， 动脉粥样硬化 LDL受到氧化应激，这可以 当脂蛋白暴露于氧化剂时， 形成其生物学特性有助于 动脉粥样硬化过程 防止LDL氧化修饰是 通过不同的抗氧化系统的主机介导，这是 存在于亲脂性隔室和水性隔室中。
英文摘要
Many studies have shown that oxidative modification of low density lipoprotein (LDL) represents a critical step in the development of atherosclerosis. LDL subjected to an oxidative stress, which can occur when the lipoprotein is exposed to oxidants, results in the formation of a particle whose biological properties contribute to the atherogenic process. Protecting against LDL oxidative modification is mediated via a host of different antioxidant systems, which are present in both the lipophilic and aqueous compartments.
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