A novel paradigm for immunity and vaccine development against group A streptococcus

由A组链球菌(GAS)引起的严重疾病每年导致50多万人死亡。由于没有有效的控制策略，迫切需要一种疫苗。一种疫苗显示出巨大的前景，但有人担心它可能不会覆盖所有的气体菌株。我们的项目旨在表明，由于使用自然免疫模型的毒株之间的交叉保护，该疫苗实际上可能具有非常广泛的覆盖范围，并可能导致对GAS免疫的理解的新范式。

Serious disease caused by the group A streptococcus (GAS) is responsible for more than 500,000 deaths per year. With no effective control strategies available, a vaccine is urgently needed. One vaccine shows great promise, but there are concerns it may not cover all GAS strains. Our project aims to show that the vaccine may in fact have very broad coverage because of cross-protection between strains using natural immunity model, and may lead to a new paradigm in understanding of GAS immunity.