A novel strategy targeting quorum sensing molecules and catalase function to block Pseudomonas aeruginosa lung infection

铜绿假单胞菌会导致严重的感染，特别是囊性纤维化、免疫功能受损、严重烧伤或长期导尿管的患者。我们将使用一种独特的战略来瞄准毒力因素，这些因素将有助于清除急性感染，防止新的慢性感染的建立，并可能降低已建立的慢性感染的严重程度。它有可能使抗生素治疗更有效，并减少所需抗生素治疗的程度。

Pseudomonas aeruginosa causes serious infections, particularly in those with Cystic Fibrosis, immunocompromise, serious burns or long term catheters. We will use a unique strategy to target virulence factors that will assist in clearing acute infection, prevent establishment of new chronic infections, and potentially reduce severity of established chronic infections. It has the potential to make antibiotic therapy more effective and lessen the extent of antibiotic therapy required.