CONTROL OF IGE MEDIATED PULMONARY INFLAMMATION IN HUMANS

描述(改编自申请人的摘要)：本提案 解决了两个关于哮喘的问题：第一，肺脏如何 豚草过敏患者的嗜酸性炎症反应不同 没有哮喘吗？第二，免疫球蛋白E介导的 炎症反应与长期和持续的 豚草过敏性哮喘患者是否存在肺嗜酸性炎症？ 对这两个问题的假想答案是GM-CSF。第一个目标是描述 分泌物增加的幅度、动力学和相对重要性 节段性抗原攻击后16天内GM-CSF的变化。在……里面 具体目标2，调查人员试图确定细胞来源 GM-CSF和AIM 3中，他们建议确定延长的表达 这种细胞因子的表达区分豚草过敏性哮喘患者和过敏性哮喘患者 犀牛。

DESCRIPTION (Adapted from the applicant's abstract): This proposal addresses two questions about asthma: first, how does the pulmonary eosinophilic inflammatory response differ in ragweed allergic subjects with and without asthma? and second, what elements of the IgE-mediated inflammatory response are associated with the prolonged and ongoing pulmonary eosinophilic inflammation observed in ragweed allergic asthmatics? The hypothesized answer to both is GM-CSF. The first aim is to characterize the magnitude, kinetics and relative importance of the increased secretion of GM-CSF over a 16-day period following segmental antigen challenge. In specific aim 2, the investigators seek to define the cellular sources of the GM-CSF and in aim 3, they propose to determine whether prolonged expression of this cytokine differentiates ragweed allergic asthmatics from allergic rhinitics.