SPORE IN BREAST CANCER

这份针对国家癌症研究所的RFA而提交的SCORE申请，将利用罗伯特·H·卢里综合癌症中心在乳腺癌研究和治疗方面的优势。该孢子将提供基础设施，将基础科学家和临床医生聚集在一起，快速测试预防、早期发现、诊断和治疗人类乳腺癌的新方法。该孢子的具体主题是：1。研究饮食和激素在乳腺癌发生中的作用。2.研究乳腺癌的细胞和分子生物学。3.评估乳腺癌风险的相关因素及预防。4.实施乳腺癌的创新转化疗法。孢子申请包括六个主要研究项目、三个职业发展项目、五个试点项目和四个支持研究的核心设施。主要研究项目有：#1.对抗雌激素的抗药性(Pi Jordan)，#2.雌激素激动剂和拮抗剂通过非经典转录途径的作用(Pi Jameson)，#3，转基因小鼠中乳腺癌发生的饮食和荷尔蒙改变(Pi Thor)，#4.乳汁、唾液和血清样本中的雌二醇水平(Pi Chatterton)，#5.抗雌激素与乳房密度和绝经前妇女(PI Morrow)，#6乳腺癌的血管抑制疗法：翻译研究(Pi Soff)。核心设施包括：行政、组织资源、临床和生物统计核心。被选为孢子计划一部分的研究人员来自多个学科，从临床程序到化学工程、病理学和微生物学-免疫学。为了保持调查人员之间的有效沟通，我们将每月召开孢子调查人员会议，每年举行一次务虚会，每月举行执行委员会会议，每名调查人员除自己的项目外，将积极参与至少一个项目(或核心)。基于我们所描述的基础设施、我们庞大的患者人数以及我们的生产力记录，我们相信罗伯特·H·卢里综合癌症中心非常适合孢子计划。

This SCORE application submitted in response to the RFA from National Cancer Institute, will take advantage of the strengths in breast cancer research and treatment that exist at the Robert H. Lurie Comprehensive Cancer Center. The SPORE will provide the infrastructure to bring together basic scientists and clinicians to rapidly test new approaches in the prevention, early detection, diagnosis and treatment of human breast cancer. The specific themes of the SPORE are: 1. To investigate the role of diet and hormones in breast carcinogenesis. 2. To study the cell and molecular biology of breast cancer. 3. To evaluate factors associated with breast cancer risk and prevention. 4. To implement innovative translational therapies for breast cancer. The SPORE application consists of six principal research projects, three career development projects, five pilot projects and four Core facilities to support the research. The principal research projects are: #1. Drug resistance to anti-estrogens (PI Jordan), #2. Actions of estrogen agonists and antagonists by non-classical transcription pathways (PI Jameson), #3, Dietary and hormonal modifications of breast carcinogenesis in transgenic mice (PI Thor), #4. Estradiol levels in breast fluid, saliva and serum samples (PI Chatterton), #5. Anti-estrogens and breast density and pre-menopausal women (PI Morrow), #6 Angiostatic therapy for breast cancer: a translational study (PI Soff). The Core facilities include: Administration,, Tissue Resources, Clinical and Biostatistical Cores. The investigators selected to be part of the SPORE Program come from a variety of disciplines ranging from Clinical Programs to Chemical Engineering, Pathology and Microbiology-Immunology. To maintain meaningful communication between investigators, we will have monthly meetings of SPORE investigators, an annual retreat, monthly meetings of the Executive Committee and each investigator will be actively involved with at least one project (or core) in addition to their own. Based on the infrastructure described, our large patient population and our track record of productivity, we believe that the Robert H. Lurie Comprehensive Cancer Center is well suited for the SPORE program.