CORE--DESIGN AND ANALYSIS

我们为跨学科烟草使用研究中心（TTURC）提出了减少烟草暴露的设计和分析核心。我们组建了一支高素质的研究人员团队，他们在设计初步研究、设计和管理临床试验、调查和干预研究、数据库开发、卫生服务研究、数据处理和统计分析方面具有专业知识。设计和分析核心是tturc的共享资源，其使命是支持和促进高质量的创新研究，重点是预防和治疗尼古丁成瘾。因此，该核心负责研究设计、数据收集和处理、质量控制、数据存储和检索、所有研究的数据分析、卫生服务研究方面的专门知识、数据管理和生物统计学。这些合作不仅针对干预研究，而且还包括两项试点研究的设计和实施。设计和分析核心将与行政核心和生物标志物核心密切合作，以促进这些相互作用并推进烟草使用研究。设计和分析核心将向其他单位提供有关方法、统计、经济和计算机问题的协助。本建议的后续部分将描述设计和分析核心活动的组织和范围。

We propose a Design and Analysis Core for the Transdisciplinary' Tobacco Use Research Center (TTURC) on tobacco exposure reduction. We have assembled a team of highly qualified investigators with expertise in the design of pilot studies, the design and management of clinical trials, surveys, and interventions studies, database development, health services research, data processing, and statistical analysis. The mission of the Design and Analysis Core, a shared resource of the TT'URC, is to support and promote high quality, innovative research focusing on the prevention and treatment of nicotine addiction. This core is thus responsible for study design, data collection and processing, quality control, data storage and retrieval, data analysis of all studies, expertise in health services research, data management and biostatistics. These collaborations are aimed not only at the intervention studies but also cover the design and conduct of the two pilot studies as well. The Design and Analysis Core will work closely with the Administrative and the Biomarkers Cores in order to facilitate these interactions and in order to advance research in tobacco use. The Design and Analysis Core will provide the other units with assistance related to methodological, statistical, economical, and computer issues. The subsequent sections of this proposal will describe the organization and the range of the Design and Analysis Core activities.