NEURAL SYSTEMS--WORD RETRIEVAL FOR ACTIONS AND SPATIAL RELATIONSHIPS IN ENGLISH

对神经系统病变患者的研究表明， 检索表示动作的单词的过程取决于 左前运动区/前额叶皮层 该项目的目的是进一步 理解词汇的神经基础，因为它涉及到 活动和空间关系。 我们将检验四个主要假设 在一系列[150]H2O PET实验中， 英语成人：（1）检索动作的单词取决于 神经结构部分地与那些潜在的检索分离， 具体实体的词语。 (2)为行动检索词语 使用可操作的伪影执行取决于神经结构 部分地与那些潜在的检索词分离， 在没有这些工件的情况下执行的操作。 (3)神经基质 动作的词语检索独立于感官形态 其中呈现动作刺激（例如，视觉[图片]与 听觉[相关声音]）。 (4)检索那些表示 空间关系取决于部分分离的神经结构 从那些对具体实体或动作的单词的潜在检索中。 在计划解决这些假设的实验中，我们希望 揭示口语各方面的神经结构 语言，从而摆脱八对语言的正常生理 可以用于评估语言受试者的处理 失语症等缺陷，并与项目2相结合，也有助于 理解聋人和听力受损者的语言过程。 这些知识最终可能有助于寻求改善 聋人手语者对语言处理的理解，并告知 制定获得性精神分裂症患者的康复战略 语言障碍如失语症。

Studies in neurological patients with lesions suggest that the normal process of retrieving words which denote actions depends on regions in left premotor/prefrontal cortex. The aim of this project is to further the understanding of the neural basis of the lexicon, as it pertains to actions and spatial relationships. We will test four principal hypotheses in a series of [150]H2O PET experiments conducted in 45 normal native English speaking adults: (1) The retrieval of words for actions depends on neural structures partially segregated from those underlying retrieval of words for concrete entities. (2) The retrieval of words for actions performed with manipulable artifacts depends on neural structures partially segregated from those underlying the retrieval of words for actions performed without such artifacts. (3) The neural substrate for the retrieval of words for actions is independent of the sensory modality in which the action stimulus is presented (e.g., visual [pictures] versus auditory [associated sounds]). (4) The retrieval of words which denote spatial relationships depends on neural structures partially segregated from those underlying retrieval of words for concrete entities or actions. In the experiments planned to address these hypotheses, we expect to uncover the neural structures underlying various aspects of spoken language, so as to shed eight on the normal physiology of language processing which may be used in the evaluation of subjects with language deficits such as aphasias, and in conjunction with Project 2, also to help understand language processes in deaf and hearing impaired individuals. Such knowledge may ultimately be of help in the search for ways to improve the understanding of language processing by deaf signers, and inform the development of rehabilitation strategies for individuals with acquired language disorders such as aphasias.