MEASUREMENT OF REPOLARIZATION

本项目的重点是人类疾病动物模型中心室复极的详细测量。子项目4.1“快速起搏诱发犬心力衰竭模型的心室复极”的总体目标是研究快速起搏诱发心力衰竭后犬心脏复极的分布和速率相关变化。研究的重点是确定体表测量反映复极特征细节的能力，即确定体表测量反映直接从心外膜和内膜区域测量的复极特征细节的能力。子项目4.2“LQT综合征犬模型的心室复极”的总体目标是研究在对照状态和药物干预后，分离的、Langendorff灌注的犬心脏悬置在躯干形的容器中，模拟LQT综合征基因典型特征的复极。本研究的主要目的是表征这些干预引起的复极改变的三维性质，并评估非侵入性（体表）测量详细反映异常复极特征的能力。本研究的基本前提是scor的主题之一，即心源性猝死的一个主要因素是异源复极特征的潜在促心律失常底物。驱动这个特殊项目的最终需求是缺乏一致的、可靠的、可靠的、敏感的非侵入性复极指数。我们建议建立和扩展SCOR当前周期中开发的方法，并将其应用于现实的犬类心律失常模型。结果将使我们能够确定在心脏直接测量的复极特性在体表上可检测到的极限。这项工作的临床意义在于开发和评估可直接应用于人类的心电图技术，以改进对可能导致猝死的复极异常的检测和监测。

The focus of this project is the detailed measurement of ventricular repolarization in animal models of human disease. The overall objective of Subproject 4.1, Ventricular Repolarization in a Rapid Pacing Induced Canine Model of Heart Failure, is to study the distribution and rate related changes of repolarization in canine hearts compromised by rapid pacing induced heart failure. Emphasis of the research is directed at determining the ability of body surface measurements to reflect details of repolarization characteristics as directed at determining the ability of body surface measurements to reflect details of repolarization characteristics as measured directly from epicardial and intramural regions. The overall aim of Subproject 4.2, Ventricular Repolarization in Canine Models of LQT Syndrome, is to study repolarization in isolated, Langendorff perfused canine hearts suspended in a torso-shaped tank during control states and following pharmacological interventions that mimic genotypically characterized LQT syndromes. The main goals of this research are to characterize the three-dimensional nature of repolarization changed induced by these interventions and to assess the ability of non-invasive (body surface) measurement to reflect in detail the characteristics of abnormal repolarization. The underlying premise of this research is one of the themes of the SCOR-that a major factor in sudden cardiac death is an underlying pro- arrhythmic substrate of heterologous repolarization characteristics. The resulting need that drives this particular project is the lack of consistent, reliable, reliable, and sensitive non-invasive indices of repolarization. We propose to build on and extend the methodologies developed in the present cycle of the SCOR and apply them under realistically pro- arrhythmic models in canines. The results will allow us to define the limits to which repolarization characteristics, as measured directly at the heart, are detectable on the body surface. The clinical significance of the work lies in the development and assessment of electrocardiographic techniques that can be Applied direct to humans to improve the detection and monitoring of repolarization abnormalities that may contribute to sudden death.