RES FACIL: LEAD, PREGNANCY, HYPERTENSION, BODY BURDEN

描述（由申请人提供）：为了利用以患者为导向的研究的潜力，重点是减少种族，民族，文化和社会经济健康差异，德鲁建议建设一个LSC，这将是一个最先进的研究中心。LSC占地4万平方英尺。四层楼高的物理结构，需要取代现有的不足的临床研究区域。目前的申请是针对LSC的第一阶段，这将包括建造外壳和建造用于临床研究活动的一楼。现有的临床研究区域包括一个六床门诊设施，占用附属县医疗设施的一个小单元，校园内的几个临时拖车，以及一个校外的卫星研究设施，用于临床研究项目。德鲁有着悠久的卓越传统，其机构使命是减少健康差距。几位教师在临床研究领域具有国内和国际公认的优势，如：1)复杂代谢紊乱（糖尿病，高血压，肥胖）；2)艾滋病毒;3)心血管及相关疾病；4)环境和生物行为对健康的影响；5)评估影响临床结果的文化和流行病学因素。不幸的是，缺乏足够的空间和设施来提供一个有凝聚力和整合的临床研究环境，这是优化研究受试者参与、保持受试者依从性、最大化项目效率和支持临床研究增长的障碍。综合临床研究环境的创建将超越这些障碍，并推动高质量的美国国立卫生研究院（NIH）资助的临床研究的完成。LSC的愿景包括在个人和社区的广泛背景下进行临床研究，并将为创新，创造性思维和加强临床科学家之间的跨学科互动提供关键环境。总之，德鲁LSC的具体目标是：1)建立一个最先进的两层研究设施（其中联邦基金将只支持一楼的建设），将nih资助的主要临床研究项目和临床调查研究的协作互动整合到一个统一的临床科学项目中；2)提供最佳的物理环境，以支持和加强学生培训、联邦资助的临床研究人员和已建立的研究人员的招聘；3)改善德鲁的临床研究环境，为致力于临床研究的初级教员和博士后学员提供高质量的培训，重点是解决日益增长和文化多样化的关键健康问题

DESCRIPTION (provided by applicant): To harness the potential of patient oriented research with a focus towards reducing racial, ethnic, cultural and socioeconomic health disparities, the Drew proposes the construction of a LSC, which would be a state-of-the-art Research Center. The LSC will be a new 40,000 sq. ft., two-story physical structure that is needed to replace existing inadequate clinical research areas. The present application is directed toward phase I of the LSC, that will include construction of the shell and build-out of the first floor for clinical research activities. The existing clinical research areas consist of a six-bed outpatient facility that occupies a small unit in the affiliated county medical facility, several temporary trailers on campus, and a satellite research facility off-campus that houses clinical research programs. Drew has a long-standing tradition of excellence, with an institutional mission to reduce health disparities. Several faculty members have nationally and internationally recognized strengths in areas of clinical investigation such as: 1) complex metabolic disorders (diabetes, hypertension, obesity); 2) HIV; 3) cardiovascular and related diseases; 4) environmental and biobehavioral influences on health; and 5) assessment of cultural and epidemiological factors that influence clinical outcomes. Unfortunately, the lack of adequate space and facilities to provide a cohesive and integrated clinical research environment is an impediment to optimizing research subject participation, maintaining subject adherence, maximizing programmatic efficiency, and supporting growth of clinical investigation. The creation of an integrated clinical research environment will transcend these barriers and advance the accomplishment of high quality National Institutes of Health (NIH)-funded clinical research. The vision of the LSC encompasses clinical investigation in the broad context of both the individual and the community, and will provide a critical environment for innovation, creative thinking, and enhanced inter-disciplinary interactions between clinical scientists. In summary, the Specific Aims of the Drew LSC are to: 1) construct a state-of-art two-story research facility (of which federal funds will support the build-out of the first floor only) that integrates a collaborative interaction of major NIH-funded clinically focused research programs and clinical investigative studies into a unified clinical sciences program; 2) provide an optimal physical environment that will support and enhance student training, federally-funded clinical investigators, and the recruitment of established researchers; and 3) improve the clinical research environment at Drew to facilitate high quality training for junior faculty and postdoctoral trainees dedicated to pursuing clinical investigation, with an emphasis on addressing critical health issues of a growing and culturally diverse nati