CRH-binding Protein: A Regulator of CRH in Stress

描述（由申请人提供）：焦虑症和抑郁症是 最常见的精神疾病这些疾病的病因是 未知，但暴露于压力和无法科普压力可能 导致这些疾病的发展。失调 促肾上腺皮质激素释放激素（CRH）系统与抑郁症有关， 某些焦虑症，使其成为一个可能的候选人， 这些紊乱。已知CRH及其受体在介导 压力反应最近的研究表明，CRH结合蛋白（CRH-BP）可能 在压力中也起着重要作用。有证据表明CRH-BP与 释放CRH并阻止其对CRH受体的作用。因此，CRH-BP可以用于 维持CRH系统的稳态，从而限制应激反应。 尽管如此，CRH-BP仍然是CRH系统的一个知之甚少的组成部分。 本论文的研究重点是CRH-BP相互作用的性质 与大脑中的CRH和CRH受体有关。审查 应激诱导CRH-BP的调节和功能可能被证明是有用的， 了解压力相关的精神病理学的潜在机制，并可能导致 涉及CRH失调的疾病的新治疗方法 系统

DESCRIPTION (provided by applicant): Anxiety disorders and depression are among the most common psychiatric disorders. The etiology of these conditions is unknown, but exposure to stress and an inability to cope with stress likely contribute to the development of these disorders. Dysregulation of the corticotropin-releasing hormone (CRH) system is associated with depression and certain anxiety disorders, making it a likely candidate for linking stress to these disorders. CRH and its receptors are known to play a role in mediating the stress response. Recent work suggests that CRH-binding protein (CRH-BP) may also play a role in stress. Evidence suggests that CRH-BP binds locally released CRH and prevents its action at CRH receptors. CRH-BP may thus serve to maintain homeostasis in the CRH system, thereby limiting the stress response. Despite this, CRH-BP remains a poorly understood component of the CRH system. The proposed research will focus on the nature of the interactions of CRH-BP with CRH and CRH receptors within the brain during stress. An examination of the stress-induced regulation and function of CRH-BP may prove useful in understanding mechanisms underlying stress-related psychopathology and may lead to new treatment approaches for disorders involving dysregulation of the CRH system.